Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)

Alessandra Arcelli; Milly Buwenge; Gabriella Macchia; Federica Bertini; Alessandra Guido; Francesco Deodato; Savino Cilla; Valerio Scotti; Maria Elena Rosetto; Igor Djan; Salvatore Parisi; Gian Carlo Mattiucci; Francesco Cellini; Michele Fiore; Pierluigi Bonomo; Liliana Belgioia; Rita Marina Niespolo; Pietro Gabriele; Mariacristina Di Marco; Nicola Simoni; Renzo Mazzarotto; Alessio Giuseppe Morganti

doi:10.1002/cam4.3330

Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)

Alessandra Arcelli, Milly Buwenge, Gabriella Macchia, Federica Bertini, Alessandra Guido, Francesco Deodato, Savino Cilla, Valerio Scotti, Maria Elena Rosetto, Igor Djan, Salvatore Parisi, Gian Carlo Mattiucci, Francesco Cellini, Michele Fiore, Pierluigi Bonomo, Liliana Belgioia, Rita Marina Niespolo, Pietro Gabriele, Mariacristina Di Marco, Nicola SimoniRenzo Mazzarotto, Alessio Giuseppe Morganti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. The aim of this study was to compare two cohorts of LAPC patients treated with SBRT ± CHT vs CRT ± CHT in terms of local control (LC), distant metastases-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and toxicity. Eighty patients were included. Patients in the two cohorts were matched according to: age ≤/>65 years, tumor diameter (two cut-offs:

Lingua originale	English
pagine (da-a)	7879-7887
Numero di pagine	9
Rivista	Cancer Medicine
Volume	9
DOI	https://doi.org/10.1002/cam4.3330
Stato di pubblicazione	Pubblicato - 2020

Keywords

Adult
Aged
Aged, 80 and over
Chemoradiotherapy
Dose Fractionation, Radiation
Female
Humans
Italy
Male
Middle Aged
Neoplasm Metastasis
Pancreatic Neoplasms
Progression-Free Survival
Radiosurgery
Retrospective Studies
Risk Factors
Time Factors
conventionally fractionated radiotherapy
pancreatic cancer
radiation therapy
stereotactic body radiotherapy

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Arcelli, A., Buwenge, M., Macchia, G., Bertini, F., Guido, A., Deodato, F., Cilla, S., Scotti, V., Rosetto, M. E., Djan, I., Parisi, S., Mattiucci, G. C., Cellini, F., Fiore, M., Bonomo, P., Belgioia, L., Niespolo, R. M., Gabriele, P., Di Marco, M., ... Morganti, A. G. (2020). Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1). Cancer Medicine, 9, 7879-7887. https://doi.org/10.1002/cam4.3330

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title = "Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)",

abstract = "Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. The aim of this study was to compare two cohorts of LAPC patients treated with SBRT ± CHT vs CRT ± CHT in terms of local control (LC), distant metastases-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and toxicity. Eighty patients were included. Patients in the two cohorts were matched according to: age ≤/>65 years, tumor diameter (two cut-offs:",

keywords = "Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Dose Fractionation, Radiation, Female, Humans, Italy, Male, Middle Aged, Neoplasm Metastasis, Pancreatic Neoplasms, Progression-Free Survival, Radiosurgery, Retrospective Studies, Risk Factors, Time Factors, conventionally fractionated radiotherapy, pancreatic cancer, radiation therapy, stereotactic body radiotherapy, Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Dose Fractionation, Radiation, Female, Humans, Italy, Male, Middle Aged, Neoplasm Metastasis, Pancreatic Neoplasms, Progression-Free Survival, Radiosurgery, Retrospective Studies, Risk Factors, Time Factors, conventionally fractionated radiotherapy, pancreatic cancer, radiation therapy, stereotactic body radiotherapy",

author = "Alessandra Arcelli and Milly Buwenge and Gabriella Macchia and Federica Bertini and Alessandra Guido and Francesco Deodato and Savino Cilla and Valerio Scotti and Rosetto, {Maria Elena} and Igor Djan and Salvatore Parisi and Mattiucci, {Gian Carlo} and Francesco Cellini and Michele Fiore and Pierluigi Bonomo and Liliana Belgioia and Niespolo, {Rita Marina} and Pietro Gabriele and {Di Marco}, Mariacristina and Nicola Simoni and Renzo Mazzarotto and Morganti, {Alessio Giuseppe}",

year = "2020",

doi = "10.1002/cam4.3330",

language = "English",

volume = "9",

pages = "7879--7887",

journal = "Cancer Medicine",

issn = "2045-7634",

publisher = "Oxford : Blackwell Publishing",

}

Arcelli, A, Buwenge, M, Macchia, G, Bertini, F, Guido, A, Deodato, F, Cilla, S, Scotti, V, Rosetto, ME, Djan, I, Parisi, S, Mattiucci, GC , Cellini, F, Fiore, M, Bonomo, P, Belgioia, L, Niespolo, RM, Gabriele, P, Di Marco, M, Simoni, N, Mazzarotto, R & Morganti, AG 2020, 'Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)', Cancer Medicine, vol. 9, pagg. 7879-7887. https://doi.org/10.1002/cam4.3330

TY - JOUR

T1 - Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)

AU - Arcelli, Alessandra

AU - Buwenge, Milly

AU - Macchia, Gabriella

AU - Bertini, Federica

AU - Guido, Alessandra

AU - Deodato, Francesco

AU - Cilla, Savino

AU - Scotti, Valerio

AU - Rosetto, Maria Elena

AU - Djan, Igor

AU - Parisi, Salvatore

AU - Mattiucci, Gian Carlo

AU - Cellini, Francesco

AU - Fiore, Michele

AU - Bonomo, Pierluigi

AU - Belgioia, Liliana

AU - Niespolo, Rita Marina

AU - Gabriele, Pietro

AU - Di Marco, Mariacristina

AU - Simoni, Nicola

AU - Mazzarotto, Renzo

AU - Morganti, Alessio Giuseppe

PY - 2020

Y1 - 2020

N2 - Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. The aim of this study was to compare two cohorts of LAPC patients treated with SBRT ± CHT vs CRT ± CHT in terms of local control (LC), distant metastases-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and toxicity. Eighty patients were included. Patients in the two cohorts were matched according to: age ≤/>65 years, tumor diameter (two cut-offs:

AB - Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. The aim of this study was to compare two cohorts of LAPC patients treated with SBRT ± CHT vs CRT ± CHT in terms of local control (LC), distant metastases-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and toxicity. Eighty patients were included. Patients in the two cohorts were matched according to: age ≤/>65 years, tumor diameter (two cut-offs:

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Chemoradiotherapy

KW - Dose Fractionation, Radiation

KW - Female

KW - Humans

KW - Italy

KW - Male

KW - Middle Aged

KW - Neoplasm Metastasis

KW - Pancreatic Neoplasms

KW - Progression-Free Survival

KW - Radiosurgery

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - conventionally fractionated radiotherapy

KW - pancreatic cancer

KW - radiation therapy

KW - stereotactic body radiotherapy

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Chemoradiotherapy

KW - Dose Fractionation, Radiation

KW - Female

KW - Humans

KW - Italy

KW - Male

KW - Middle Aged

KW - Neoplasm Metastasis

KW - Pancreatic Neoplasms

KW - Progression-Free Survival

KW - Radiosurgery

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - conventionally fractionated radiotherapy

KW - pancreatic cancer

KW - radiation therapy

KW - stereotactic body radiotherapy

UR - http://hdl.handle.net/10807/203416

U2 - 10.1002/cam4.3330

DO - 10.1002/cam4.3330

M3 - Article

SN - 2045-7634

VL - 9

SP - 7879

EP - 7887

JO - Cancer Medicine

JF - Cancer Medicine

ER -

Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1)

Abstract

Keywords

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