TY - JOUR
T1 - Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review
AU - Bonosi, Lapo
AU - Silven, Manikon Poullay
AU - Biancardino, Antonio Alessandro
AU - Sciortino, Andrea
AU - Giammalva, Giuseppe Roberto
AU - Scerrati, Alba
AU - Sturiale, Carmelo Lucio
AU - Albanese, Alessio
AU - Tumbiolo, Silvana
AU - Visocchi, Massimiliano
AU - Iacopino, Domenico Gerardo
AU - Maugeri, Rosario
PY - 2022
Y1 - 2022
N2 - Spinal cord injury (SCI) is a devastating condition with a significant medical and socioeconomic impact. To date, no effective treatment is available that can enable neuronal regeneration and recovery of function at the damaged level. This is thought to be due to scar formation, axonal degeneration and a strong inflammatory response inducing a loss of neurons followed by a cascade of events that leads to further spinal cord damage. Many experimental studies demonstrate the therapeutic effect of stem cells in SCI due to their ability to differentiate into neuronal cells and release neurotrophic factors. Therefore, it appears to be a valid strategy to use in the field of regenerative medicine. This review aims to provide an up-to-date summary of the current research status, challenges, and future directions for stem cell therapy in SCI models, providing an overview of this constantly evolving and promising field.
AB - Spinal cord injury (SCI) is a devastating condition with a significant medical and socioeconomic impact. To date, no effective treatment is available that can enable neuronal regeneration and recovery of function at the damaged level. This is thought to be due to scar formation, axonal degeneration and a strong inflammatory response inducing a loss of neurons followed by a cascade of events that leads to further spinal cord damage. Many experimental studies demonstrate the therapeutic effect of stem cells in SCI due to their ability to differentiate into neuronal cells and release neurotrophic factors. Therefore, it appears to be a valid strategy to use in the field of regenerative medicine. This review aims to provide an up-to-date summary of the current research status, challenges, and future directions for stem cell therapy in SCI models, providing an overview of this constantly evolving and promising field.
KW - bioengineering
KW - nanotechnology
KW - neuronal regeneration
KW - scaffolds
KW - spinal cord injury
KW - stem cell therapy
KW - bioengineering
KW - nanotechnology
KW - neuronal regeneration
KW - scaffolds
KW - spinal cord injury
KW - stem cell therapy
UR - http://hdl.handle.net/10807/304077
U2 - 10.3390/ijms232112996
DO - 10.3390/ijms232112996
M3 - Article
SN - 1422-0067
VL - 23
SP - N/A-N/A
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -