Stem cell-mediated muscle regeneration and repair in aging and neuromuscular diseases

Bianca Maria Scicchitano, Cristina Giacinti, A Musarò, L Pelosi, G Dobrowolny, L Barberi, C Nardis, D Coletti, S Adamo, M. Molinaro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

One of the most exciting aspirations of current medical science is the regeneration of damaged body parts. The capacity of adult tissues to regenerate in response to injury stimuli represents an important homeostatic process that until recently was thought to be limited in mammals to tissues with high turnover such as blood and skin. However, it is now generally accepted that each tissue type, even those considered post-mitotic, such as nerve or muscle, contains a reserve of undifferentiated progenitor cells, loosely termed stem cells, participating in tissue regeneration and repair. Skeletal muscle regeneration is a coordinate process in which several factors are sequentially activated to maintain and preserve muscle structure and function upon injury stimuli. In this review, we will discuss the role of stem cells in muscle regeneration and repair and the critical role of specific factors, such as IGF-1, vasopressin and TNF-alpha, in the modulation of the myogenic program and in the regulation of muscle regeneration and homeostasis.
Lingua originaleEnglish
pagine (da-a)35-43
Numero di pagine9
RivistaEuropean Journal of Histochemistry
Volume51
Stato di pubblicazionePubblicato - 2007

Keywords

  • Regeneration

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