Statistical properties of urn designs in clinical trials

Andrea Ghiglietti, Anna Maria Paganoni

Risultato della ricerca: Contributo in libroContributo a convegno

Abstract

We propose a response-adaptive design, described in terms of urn model, whose allocation proportion converges to prespecified values. The main asymptotic results concerning the urn designs are presented and discussed. We adopt the urn model to implement the random allocation procedure of an experiment that aims at testing the mean effect of two treatments. We conduct a statistical analysis on the inferential performance of different tests and we show that, given a non adaptive test T0, the response adaptive model constructs a test T that is better than T0, in terms of (a) higher power and (b) fewer subjects assigned to the inferior treatment. A retrospective real case study is presented.
Lingua originaleEnglish
Titolo della pubblicazione ospiteProceedings of XLVII Scientific meeting of the Italian Statistical Society
Pagine1-8
Numero di pagine8
Stato di pubblicazionePubblicato - 2014
EventoXLVII Scientific meeting of the Italian Statistical Society - Cagliari
Durata: 11 giu 201413 giu 2014

Convegno

ConvegnoXLVII Scientific meeting of the Italian Statistical Society
CittàCagliari
Periodo11/6/1413/6/14

Keywords

  • Clinical trials
  • Randomly Reinforced Urns
  • Tests based on adaptive procedures

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