State of the art of fluorescence guided techniques in neurosurgery

Giuseppe La Rocca*, Giuseppe Maria Della Pepa, Grazia Menna, Roberto Altieri, Tamara Ius, Alessandro Rapisarda, Alessandro Olivi, Giovanni Sabatino

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


Achieving a safe and extensive neoplasm resection can be considered the main goal of brain tumor surgery. This paper is first aimed at providing an overview of the evolution of those tools serving the purpose. From the dawn of neurosurgery to the present days, major innovations have followed one another. However, those techniques may frequently lack of an instant biological feedback on the true extension and the infiltration of the tumor. Intraoperative fluorescence modalities could indeed fill this gap. Fluorescence guided surgery will be therefore introduced and discussed in this context. Our focus will be on the most common fluorescence techniques used in neurosurgery, namely 5-aminolevulinic acid, sodium fluorescein and in indocyanine green. Mode of action, strengths and weaknesses and level of evidence of each modality will be discussed.
Lingua originaleEnglish
pagine (da-a)619-624
Numero di pagine6
RivistaJournal of Neurosurgical Sciences
Stato di pubblicazionePubblicato - 2019


  • Aminolevulinic acid
  • Brain neoplasms
  • Fluorescein
  • Glioma
  • Indocyanine green
  • Survival


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