Starry sky pattern predicts RAS pathway activation in NPM1-mutated acute myeloid leukemia

Mutations of the nucleophosmin (NPM1) gene represent the most common genetic lesion in adult acute myeloid leukemia (AML), occurring in about one-third of cases and 60% of AML with normal cytogenetics.1 Due to its unique molecular, pathological and clinical features,2, 3 NPM1-mutated AML is now recognized as a distinct entity in the 2022 International Consensus4 and World Health Organization (WHO) 5th edition5 classifications of myeloid neoplasms.