Abstract
Objective - To compare the effectiviness of spyramicin/ cotrimoxazole (Sp/C) versus\r\npyrimethamine/sulphonamide (Pyr/Sul) and spyramicin alone (Spy) on mother-to-child transmission of toxoplasmosis infection in pregnancy.\r\nStudy Design - Retrospective study of pregnant women evaluated for suspected toxoplasmosis between 1992 and 2011.\r\nResults - 120 mothers and their 123 newborns were included.Prenatal treatment consisted of spyramicin in 43 mothers (35%), spyramicin/cotromoxazole in 70 (56.9%),pyrimethamine/ sulphonamide in 10 (8.1%).A trend toward reduction in toxoplasmosis transmission was found when Sp/C was compared with Pyr/Sul and particularly with Spy alone (p= 0.014).In particular, Spy increased the risk of congenital infection when compared with Sp/C (OR 4.368; 95% CI: 1.253–15.219), but there was no significant reduction when Sp/C was compared with Pyr/Sul\r\n(OR 1.83; 95% CI: 0.184–18.274).\r\nConclusion - The treatment based on Sp/C has significant efficacy in reducing maternal-fetal transmission of Toxoplasma Gondii when compared to Pyr/Sul and particularly to Spy.\r\nRandomized controlled trials would be required.
Lingua originale | Inglese |
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pagine (da-a) | 90-94 |
Numero di pagine | 5 |
Rivista | Journal of Perinatology |
Volume | 35 |
Numero di pubblicazione | 2 |
DOI | |
Stato di pubblicazione | Pubblicato - 2015 |
All Science Journal Classification (ASJC) codes
- Pediatria, Perinatologia e Salute del Bambino
- Ostetricia e Ginecologia
Keywords
- Follou-up neonatale
- Postnatal follow-up
- Pregnancy
- Prenatal therapy
- Terapia prenatale
- Toxoplasmosi
- Toxoplasmosis
- gravidanza