Spiramycin/cotrimoxazole versus pyrimethamine/sulfonamide and spiramycin alone for the treatment of toxoplasmosis in pregnancy

Piero Valentini, Danilo Buonsenso*, Giovanni Barone, Daniele Serranti, Roberta Calzedda, Manuela Ceccarelli, Domenico Speziale, Rosalba Ricci, Lucia Masini

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolopeer review

23 Citazioni (Scopus)

Abstract

Objective - To compare the effectiviness of spyramicin/ cotrimoxazole (Sp/C) versus\r\npyrimethamine/sulphonamide (Pyr/Sul) and spyramicin alone (Spy) on mother-to-child transmission of toxoplasmosis infection in pregnancy.\r\nStudy Design - Retrospective study of pregnant women evaluated for suspected toxoplasmosis between 1992 and 2011.\r\nResults - 120 mothers and their 123 newborns were included.Prenatal treatment consisted of spyramicin in 43 mothers (35%), spyramicin/cotromoxazole in 70 (56.9%),pyrimethamine/ sulphonamide in 10 (8.1%).A trend toward reduction in toxoplasmosis transmission was found when Sp/C was compared with Pyr/Sul and particularly with Spy alone (p= 0.014).In particular, Spy increased the risk of congenital infection when compared with Sp/C (OR 4.368; 95% CI: 1.253–15.219), but there was no significant reduction when Sp/C was compared with Pyr/Sul\r\n(OR 1.83; 95% CI: 0.184–18.274).\r\nConclusion - The treatment based on Sp/C has significant efficacy in reducing maternal-fetal transmission of Toxoplasma Gondii when compared to Pyr/Sul and particularly to Spy.\r\nRandomized controlled trials would be required.
Lingua originaleInglese
pagine (da-a)90-94
Numero di pagine5
RivistaJournal of Perinatology
Volume35
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2015

All Science Journal Classification (ASJC) codes

  • Pediatria, Perinatologia e Salute del Bambino
  • Ostetricia e Ginecologia

Keywords

  • Follou-up neonatale
  • Postnatal follow-up
  • Pregnancy
  • Prenatal therapy
  • Terapia prenatale
  • Toxoplasmosi
  • Toxoplasmosis
  • gravidanza

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