TY - JOUR
T1 - Spine Instability Neoplastic Score (SINS) as a Predictive Tool in Conventional Radiotherapy: A Narrative Review
AU - Pezzulla, Donato
AU - Re, Alessia
AU - Cilla, Savino
AU - Ferro, Milena
AU - Romano, Carmela
AU - Bonome, Paolo
AU - Di Franco, Rossella
AU - Muto, Paolo
AU - Mattiucci, Gian Carlo
AU - Deodato, Francesco
AU - Macchia, Gabriella
PY - 2023
Y1 - 2023
N2 - Aims: This narrative review seeks to identify the SINS score application in the radiation oncology field. Methods: This literature review was performed searching papers on MEDLINE published from January 2010 to August 2022. Results: In terms of vertebral painful lesions and RT symptomatic responses, the SINS score could be an interesting aid in order to choose the right therapeutic approach. Lesions with higher level of instability, and therefore higher SINS score, could did not find any significant benefit from radiation therapy which is more effective on the tumor-related pain component. For SINS as a predictor of adverse event after RT or its changes after RT, we obtained contrasting results. Conclusions: The reported few experiences showed ambiguous conclusions. Further prospective studies are needed.
AB - Aims: This narrative review seeks to identify the SINS score application in the radiation oncology field. Methods: This literature review was performed searching papers on MEDLINE published from January 2010 to August 2022. Results: In terms of vertebral painful lesions and RT symptomatic responses, the SINS score could be an interesting aid in order to choose the right therapeutic approach. Lesions with higher level of instability, and therefore higher SINS score, could did not find any significant benefit from radiation therapy which is more effective on the tumor-related pain component. For SINS as a predictor of adverse event after RT or its changes after RT, we obtained contrasting results. Conclusions: The reported few experiences showed ambiguous conclusions. Further prospective studies are needed.
KW - SINS
KW - radiotherapy
KW - vertebral instability
KW - SINS
KW - radiotherapy
KW - vertebral instability
UR - https://publicatt.unicatt.it/handle/10807/326061
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85174309814&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174309814&origin=inward
U2 - 10.1080/07357907.2023.2269566
DO - 10.1080/07357907.2023.2269566
M3 - Article
SN - 0735-7907
VL - 41
SP - 774
EP - 780
JO - Cancer Investigation
JF - Cancer Investigation
IS - 9
ER -
