Spinal involvement in mucopolysaccharidoses: a review

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

Mucopolysaccharidoses (MPS) represent a group of inheritable lysosomal storage diseases caused by mutations in the genes coding for enzymes involved in catabolism of different glycosaminoglycans (GAGs). They are clinically heterogeneous multisystemic diseases, often involving the spine. Bony abnormalities of the spine included in the so-called dysostosis multiplex and GAG deposits in the dura mater and supporting ligaments can result in spinal cord compression, which can lead to compressive myelopathy. Spinal involvement is a major cause of morbidity and mortality in some MPS (e.g., MPS IVA, VI, and I), and early radiological diagnosis is critical in preventing or arresting neurological deterioration and loss of function.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaCHILDS NERVOUS SYSTEM
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Spinal
  • mucopolysaccharidoses

Fingerprint Entra nei temi di ricerca di 'Spinal involvement in mucopolysaccharidoses: a review'. Insieme formano una fingerprint unica.

Cita questo