Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Elisa Petruccioli; Alessandra Romagnoli; Marco Corazzari; Eliana M. Coccia; Ornella Butera; Giovanni Delogu; Mauro Piacentini; Enrico Girardi; Gian Maria Fimia; Delia Goletti

doi:10.1093/infdis/jis226

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Elisa Petruccioli, Alessandra Romagnoli, Marco Corazzari, Eliana M. Coccia, Ornella Butera, Giovanni Delogu, Mauro Piacentini, Enrico Girardi, Gian Maria Fimia, Delia Goletti

Risultato della ricerca: Contributo in rivista › Articolo › peer review

36 Citazioni (Scopus)

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

Lingua originale	Inglese
pagine (da-a)	1425-1435
Numero di pagine	11
Rivista	THE JOURNAL OF INFECTIOUS DISEASES
Volume	205
DOI	https://doi.org/10.1093/infdis/jis226
Stato di pubblicazione	Pubblicato - 2012

Keywords

Autophagy
Blotting, Western
Cell Communication
Humans
Interferon-gamma
Macrophages
Microscopy, Confocal
Mycobacterium tuberculosis
Phagosomes
RNA-Binding Proteins
Real-Time Polymerase Chain Reaction
Stem Cells
T-Lymphocytes
Tuberculosis
Tumor Necrosis Factor-alpha

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1093/infdis/jis226

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{8e963c47da964d0cb224a06b1adc0b23,

title = "Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages",

abstract = "Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.",

keywords = "Autophagy, Blotting, Western, Cell Communication, Humans, Interferon-gamma, Macrophages, Microscopy, Confocal, Mycobacterium tuberculosis, Phagosomes, RNA-Binding Proteins, Real-Time Polymerase Chain Reaction, Stem Cells, T-Lymphocytes, Tuberculosis, Tumor Necrosis Factor-alpha, Autophagy, Blotting, Western, Cell Communication, Humans, Interferon-gamma, Macrophages, Microscopy, Confocal, Mycobacterium tuberculosis, Phagosomes, RNA-Binding Proteins, Real-Time Polymerase Chain Reaction, Stem Cells, T-Lymphocytes, Tuberculosis, Tumor Necrosis Factor-alpha",

author = "Elisa Petruccioli and Alessandra Romagnoli and Marco Corazzari and Coccia, \{Eliana M.\} and Ornella Butera and Giovanni Delogu and Mauro Piacentini and Enrico Girardi and Fimia, \{Gian Maria\} and Delia Goletti",

year = "2012",

doi = "10.1093/infdis/jis226",

language = "English",

volume = "205",

pages = "1425--1435",

journal = "THE JOURNAL OF INFECTIOUS DISEASES",

issn = "0022-1899",

publisher = "University of Chicago Press:PO Box 37005, Journals Division:Chicago, IL 60637:(877)705-1878, (877)705-1878, (773)753-2247, EMAIL: [email protected], INTERNET: http://www.press.uchicago.edu, Fax: (877)705-1879, (773)753-0811",

}

TY - JOUR

T1 - Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

AU - Petruccioli, Elisa

AU - Romagnoli, Alessandra

AU - Corazzari, Marco

AU - Coccia, Eliana M.

AU - Butera, Ornella

AU - Delogu, Giovanni

AU - Piacentini, Mauro

AU - Girardi, Enrico

AU - Fimia, Gian Maria

AU - Goletti, Delia

PY - 2012

Y1 - 2012

N2 - Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

AB - Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

KW - Autophagy

KW - Blotting, Western

KW - Cell Communication

KW - Humans

KW - Interferon-gamma

KW - Macrophages

KW - Microscopy, Confocal

KW - Mycobacterium tuberculosis

KW - Phagosomes

KW - RNA-Binding Proteins

KW - Real-Time Polymerase Chain Reaction

KW - Stem Cells

KW - T-Lymphocytes

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

KW - Autophagy

KW - Blotting, Western

KW - Cell Communication

KW - Humans

KW - Interferon-gamma

KW - Macrophages

KW - Microscopy, Confocal

KW - Mycobacterium tuberculosis

KW - Phagosomes

KW - RNA-Binding Proteins

KW - Real-Time Polymerase Chain Reaction

KW - Stem Cells

KW - T-Lymphocytes

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

UR - http://hdl.handle.net/10807/3577

U2 - 10.1093/infdis/jis226

DO - 10.1093/infdis/jis226

M3 - Article

SN - 0022-1899

VL - 205

SP - 1425

EP - 1435

JO - THE JOURNAL OF INFECTIOUS DISEASES

JF - THE JOURNAL OF INFECTIOUS DISEASES

ER -

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo