Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

E Petruccioli; A Romagnoli; M Corazzari; Em Coccia; O Butera; Giovanni Delogu; M Piacentini; E Girardi; Gm Fimia; D. Goletti

doi:10.1093/infdis/jis226

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

E Petruccioli, A Romagnoli, M Corazzari, Em Coccia, O Butera, Giovanni Delogu, M Piacentini, E Girardi, Gm Fimia, D. Goletti

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

36 Citazioni (Scopus)

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

Lingua originale	English
pagine (da-a)	1425-1435
Numero di pagine	11
Rivista	THE JOURNAL OF INFECTIOUS DISEASES
Volume	205
DOI	https://doi.org/10.1093/infdis/jis226
Stato di pubblicazione	Pubblicato - 2012

Keywords

Autophagy
Blotting, Western
Cell Communication
Humans
Interferon-gamma
Macrophages
Microscopy, Confocal
Mycobacterium tuberculosis
Phagosomes
RNA-Binding Proteins
Real-Time Polymerase Chain Reaction
Stem Cells
T-Lymphocytes
Tuberculosis
Tumor Necrosis Factor-alpha

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10.1093/infdis/jis226

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title = "Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages",

abstract = "Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.",

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author = "E Petruccioli and A Romagnoli and M Corazzari and Em Coccia and O Butera and Giovanni Delogu and M Piacentini and E Girardi and Gm Fimia and D. Goletti",

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TY - JOUR

T1 - Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

AU - Petruccioli, E

AU - Romagnoli, A

AU - Corazzari, M

AU - Coccia, Em

AU - Butera, O

AU - Delogu, Giovanni

AU - Piacentini, M

AU - Girardi, E

AU - Fimia, Gm

AU - Goletti, D.

PY - 2012

Y1 - 2012

N2 - Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

AB - Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

KW - Autophagy

KW - Blotting, Western

KW - Cell Communication

KW - Humans

KW - Interferon-gamma

KW - Macrophages

KW - Microscopy, Confocal

KW - Mycobacterium tuberculosis

KW - Phagosomes

KW - RNA-Binding Proteins

KW - Real-Time Polymerase Chain Reaction

KW - Stem Cells

KW - T-Lymphocytes

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

KW - Autophagy

KW - Blotting, Western

KW - Cell Communication

KW - Humans

KW - Interferon-gamma

KW - Macrophages

KW - Microscopy, Confocal

KW - Mycobacterium tuberculosis

KW - Phagosomes

KW - RNA-Binding Proteins

KW - Real-Time Polymerase Chain Reaction

KW - Stem Cells

KW - T-Lymphocytes

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

UR - http://hdl.handle.net/10807/3577

U2 - 10.1093/infdis/jis226

DO - 10.1093/infdis/jis226

M3 - Article

SN - 0022-1899

VL - 205

SP - 1425

EP - 1435

JO - THE JOURNAL OF INFECTIOUS DISEASES

JF - THE JOURNAL OF INFECTIOUS DISEASES

ER -

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Abstract

Keywords

OSS delle Nazioni Unite

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