Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Giovanni Delogu, E Petruccioli, A Romagnoli, M Corazzari, Em Coccia, O Butera, M Piacentini, E Girardi, Gm Fimia, D. Goletti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

36 Citazioni (Scopus)

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.
Lingua originaleEnglish
pagine (da-a)1425-1435
Numero di pagine11
RivistaTHE JOURNAL OF INFECTIOUS DISEASES
Volume205
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Autophagy
  • Blotting, Western
  • Cell Communication
  • Humans
  • Interferon-gamma
  • Macrophages
  • Microscopy, Confocal
  • Mycobacterium tuberculosis
  • Phagosomes
  • RNA-Binding Proteins
  • Real-Time Polymerase Chain Reaction
  • Stem Cells
  • T-Lymphocytes
  • Tuberculosis
  • Tumor Necrosis Factor-alpha

Fingerprint Entra nei temi di ricerca di 'Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages'. Insieme formano una fingerprint unica.

Cita questo