Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2

Joseph A. Bell; Elizabeth R. Davies; Christopher J. Brereton; Milica Vukmirovic; James J.W. Roberts; Kerry Lunn; Leanne Wickens; Franco Conforti; Robert A. Ridley; Jessica Ceccato; Lucy N. Sayer; David A. Johnston; Andres F. Vallejo; Aiman Alzetani; Sanjay Jogai; Ben G. Marshall; Aurelie Fabre; Luca Richeldi; Phillip D. Monk; Paul Skipp; Naftali Kaminski; Emily Offer; Yihua Wang; Donna E. Davies; Mark G. Jones

doi:10.1016/j.xcrm.2024.101695

Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2

Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul SkippNaftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones

Risultato della ricerca: Contributo in rivista › Articolo

Lingua originale	Inglese
pagine (da-a)	3-20
Numero di pagine	18
Rivista	Cell Reports Medicine
DOI	https://doi.org/10.1016/j.xcrm.2024.101695
Stato di pubblicazione	Pubblicato - 2024

Keywords

LOXL2
disease-relevant biomimetic models
fibrosis
spatial transcriptomics
target engagement

Accesso al documento

10.1016/j.xcrm.2024.101695

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Bell, J. A., Davies, E. R., Brereton, C. J., Vukmirovic, M., Roberts, J. J. W., Lunn, K., Wickens, L., Conforti, F., Ridley, R. A., Ceccato, J., Sayer, L. N., Johnston, D. A., Vallejo, A. F., Alzetani, A., Jogai, S., Marshall, B. G., Fabre, A., Richeldi, L., Monk, P. D., ... Jones, M. G. (2024). Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2. Cell Reports Medicine, 3-20. https://doi.org/10.1016/j.xcrm.2024.101695

@article{89d28b1b2af341ad8dde4d1ec073930a,

title = "Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2",

keywords = "LOXL2, disease-relevant biomimetic models, fibrosis, spatial transcriptomics, target engagement, LOXL2, disease-relevant biomimetic models, fibrosis, spatial transcriptomics, target engagement",

author = "Bell, \{Joseph A.\} and Davies, \{Elizabeth R.\} and Brereton, \{Christopher J.\} and Milica Vukmirovic and Roberts, \{James J.W.\} and Kerry Lunn and Leanne Wickens and Franco Conforti and Ridley, \{Robert A.\} and Jessica Ceccato and Sayer, \{Lucy N.\} and Johnston, \{David A.\} and Vallejo, \{Andres F.\} and Aiman Alzetani and Sanjay Jogai and Marshall, \{Ben G.\} and Aurelie Fabre and Luca Richeldi and Monk, \{Phillip D.\} and Paul Skipp and Naftali Kaminski and Emily Offer and Yihua Wang and Davies, \{Donna E.\} and Jones, \{Mark G.\}",

year = "2024",

doi = "10.1016/j.xcrm.2024.101695",

language = "English",

pages = "3--20",

journal = "Cell Reports Medicine",

issn = "2666-3791",

publisher = "Cell Press",

}

Bell, JA, Davies, ER, Brereton, CJ, Vukmirovic, M, Roberts, JJW, Lunn, K, Wickens, L, Conforti, F, Ridley, RA, Ceccato, J, Sayer, LN, Johnston, DA, Vallejo, AF, Alzetani, A, Jogai, S, Marshall, BG, Fabre, A, Richeldi, L, Monk, PD, Skipp, P, Kaminski, N, Offer, E, Wang, Y, Davies, DE & Jones, MG 2024, 'Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2', Cell Reports Medicine, pagg. 3-20. https://doi.org/10.1016/j.xcrm.2024.101695

TY - JOUR

T1 - Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2

AU - Bell, Joseph A.

AU - Davies, Elizabeth R.

AU - Brereton, Christopher J.

AU - Vukmirovic, Milica

AU - Roberts, James J.W.

AU - Lunn, Kerry

AU - Wickens, Leanne

AU - Conforti, Franco

AU - Ridley, Robert A.

AU - Ceccato, Jessica

AU - Sayer, Lucy N.

AU - Johnston, David A.

AU - Vallejo, Andres F.

AU - Alzetani, Aiman

AU - Jogai, Sanjay

AU - Marshall, Ben G.

AU - Fabre, Aurelie

AU - Richeldi, Luca

AU - Monk, Phillip D.

AU - Skipp, Paul

AU - Kaminski, Naftali

AU - Offer, Emily

AU - Wang, Yihua

AU - Davies, Donna E.

AU - Jones, Mark G.

PY - 2024

Y1 - 2024

KW - LOXL2

KW - disease-relevant biomimetic models

KW - fibrosis

KW - spatial transcriptomics

KW - target engagement

KW - LOXL2

KW - disease-relevant biomimetic models

KW - fibrosis

KW - spatial transcriptomics

KW - target engagement

UR - http://hdl.handle.net/10807/289158

U2 - 10.1016/j.xcrm.2024.101695

DO - 10.1016/j.xcrm.2024.101695

M3 - Article

SN - 2666-3791

SP - 3

EP - 20

JO - Cell Reports Medicine

JF - Cell Reports Medicine

ER -