Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

Amankeldi A. Salybekov; Ainur K. Salybekova; Roberto Pola; Takayuki Asahara

doi:10.3390/ijms19103040

Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

Amankeldi A. Salybekov, Ainur K. Salybekova, Roberto Pola, Takayuki Asahara

Tokai University

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

8 Citazioni (Scopus)

Abstract

The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the SHH signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	International Journal of Molecular Sciences
Volume	2018
DOI	https://doi.org/10.3390/ijms19103040
Stato di pubblicazione	Pubblicato - 2018

Keywords

Hedgehog

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.3390/ijms19103040

Altri file e collegamenti

Open Access link a IRIS PubliCatt

Cita questo

@article{71e161d0df6e42cbbda10cc50e839ecd,

title = "Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine",

abstract = "The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the SHH signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.",

keywords = "Hedgehog, Hedgehog",

author = "Salybekov, {Amankeldi A.} and Salybekova, {Ainur K.} and Roberto Pola and Takayuki Asahara",

year = "2018",

doi = "10.3390/ijms19103040",

language = "English",

volume = "2018",

pages = "N/A--N/A",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI, cop. 2005-",

}

TY - JOUR

T1 - Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

AU - Salybekov, Amankeldi A.

AU - Salybekova, Ainur K.

AU - Pola, Roberto

AU - Asahara, Takayuki

PY - 2018

Y1 - 2018

N2 - The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the SHH signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.

AB - The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the SHH signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.

KW - Hedgehog

UR - http://hdl.handle.net/10807/133773

U2 - 10.3390/ijms19103040

DO - 10.3390/ijms19103040

M3 - Article

SN - 1422-0067

VL - 2018

SP - N/A-N/A

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

ER -

Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo