Soluble urokinase-type plasminogen activator receptor as a putative marker of male accessory gland inflammation

Alfredo Pontecorvi, Silvia Baroni, Chiara Autilio, Renato Morelli, Domenico Milardi, Giuseppe Grande, Riccardo Marana, Cecilia Zuppi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

The association between male accessory gland infection/inflammation (MAGI) and infertility is well-known in clinical practice. Standard semen analysis, leukocytospermia, and microbiological tests are often not enough accurate for a diagnosis. A large amount of biochemical parameters in seminal plasma have been suggested as inflammation markers, however, there is not yet a sensitive and specific biomarker that accurately identifies MAGI. We investigated the presence of soluble urokinase-type plasminogen activator receptor (suPAR), known marker of systemic inflammation, in the seminal plasma to evaluate its possible involvement in urogenital tract inflammation. On the basis of andrological evaluation, including spermiogram and ultrasound findings, we selected 76 patients with MAGI and 30 healthy men as control group. Patients were classified according to the results of the semen culture in group A (n = 28) presenting a bacterial MAGI and group B (n = 48) with abacterial MAGI. C-reactive protein (CRP), total protein (TP), procalcitonin (PCT), leukocytes peroxidase (LP), and suPAR concentrations were assayed on seminal plasma. Spermiogram parameters were significantly lower in the patients with MAGI than in controls. CRP, TP, PCT, and LP did not differ in MAGI vs.
Lingua originaleEnglish
pagine (da-a)1054-1061
Numero di pagine8
RivistaAndrology
Volume3
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • infection
  • inflammation
  • male accessory gland infection/inflammation
  • semen analysis
  • sperm quality parameters
  • subfertility

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