Sodium oxybate in maintaining alcohol abstinence in alcoholic patients with and without psychiatric comorbidity.

Giovanni Addolorato, Lorenzo Leggio, Fabio Caputo, S Francini, R Brambilla, F Vigna Taglianti, M Stoppo, A Del Re, G Zoli, M. Bernardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

Sodium oxybate (SMO) is a GABA-ergic drug currently used for the treatment of alcohol-dependence in some European countries. In particular, clinical studies have shown a role of SMO in promoting alcohol abstinence, as well as in relieving withdrawal symptoms. The aim of this study was to describe alcohol abstinence and the onset of craving for and abuse of SMO in alcohol-dependent subjects with and without psychiatric co-morbidity. Forty-eight patients were enrolled and classified into two groups: group A (20 alcoholics without any psychiatric co-morbidity) and group B (28 alcoholics with a psychiatric co-morbidity). All patients were treated with oral SMO (50mg/kg of body weight t.i.d.) for 12weeks. Alcohol abstinence as well as alcohol drinking during the 12weeks of treatment did not differ between the two groups at the end of treatment (p=0.9). In addition, a reduction of alcohol intake in both groups has been observed (p<0.0001). On the other hand, craving for SMO was significantly more frequent in group B than group A (p=0.001). Cases of SMO abuse were observed in almost 10% of group B patients. In conclusion, alcohol abstinence achieved through SMO administration does not differ in patients with and without psychiatric co-morbidity. However, alcoholics with co-morbid borderline disorders appear to be at high risk of developing craving for and abuse of the drug; therefore, SMO may not be indicated in these patients.
Lingua originaleEnglish
pagine (da-a)450-456
Numero di pagine7
RivistaEuropean Neuropsychopharmacology
Stato di pubblicazionePubblicato - 2011

Keywords

  • alcoholism
  • psychiatric comorbidity
  • sodium oxybate

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