Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature.

Maria Teresa Viscomi, Luisa Lo Iacono, Alessandro Valzania, Federica Visco-Comandini, Eleonora Aricò, Luciano Castiello, Diego Oddi, Francesca R. D'Amato, Elisa Bisicchia, Olga Ermakova, Stefano Puglisi-Allegra, Valeria Carola

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and mediate the greater risk of relapse are poorly understood and knowledge of risk factors is to date extremely limited. In this study, we modeled childhood maltreatment by exposing juvenile mice to a threatening social experience (social stressed, S-S). We showed that S-S experience influenced the propensity to reinstate cocaine-seeking after periods of withdrawal in adulthood. By exploring global gene expression in blood leukocytes we found that this behavioral phenotype was associated with greater blood coagulation. In parallel, impairments in brain microvasculature were observed in S-S mice. Furthermore, treatment with an anticoagulant agent during withdrawal abolished the susceptibility to reinstate cocaine-seeking in S-S mice. These findings provide novel insights into a possible molecular mechanism by which childhood maltreatment heightens the risk for relapse in cocaine-dependent individuals.
Lingua originaleEnglish
pagine (da-a)911-922
Numero di pagine12
RivistaAddiction Biology
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • blood coagulation

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