Small bowel bacterial overgrowth and type 1 diabetes

Veronica Ojetti, Dario Pitocco, Emidio Scarpellini, Francesco Zaccardi, Franco Scaldaferri, Giovanni Gigante, Giovanni Battista Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

31 Citazioni (Scopus)


BACKGROUND: Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts. AIM: To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy. PATIENTS AND METHODS: 25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test. RESULTS: 2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05). CONCLUSIONS: Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements.
Lingua originaleEnglish
pagine (da-a)419-423
Numero di pagine5
RivistaEuropean Review for Medical and Pharmacological Sciences
Stato di pubblicazionePubblicato - 2009


  • Adult
  • Bacteria
  • Diabetes Mellitus, Type 1
  • Diabetic Neuropathies
  • Female
  • Humans
  • Intestinal Diseases
  • Intestine, Small
  • Male
  • Middle Aged


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