TY - JOUR
T1 - Sleep-related modifications of EEG connectivity in the sensory-motor networks in Huntington Disease: An eLORETA study and review of the literature
AU - Piano, Carla
AU - Imperatori, Claudio
AU - Losurdo, Anna
AU - Bentivoglio, Anna Rita
AU - Cortelli, Pietro
AU - Della Marca, Giacomo
PY - 2017
Y1 - 2017
N2 - Objective To evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD). Methods 23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA). Results In wake, HD patients showed an increase of delta lagged phase synchronization (T = 3.60; p < 0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4. In NREM, HD patients showed an increase of delta lagged phase synchronization (T = 3.56; p < 0.05) among left BA 1-2-3 and right BA 6-8. In REM, HD patients showed an increase of lagged phase synchronization (T = 3.60; p < 0.05) among the BA 6-8 bilaterally (delta band); left BA 1-2-3 and right BA 1-2-3 (theta); left BA 1-2-3 and right BA 4 (theta); left BA 1-2-3 and right BA 1-2-3 (alpha). Conclusions Our results may reflect an abnormal function of the motor areas or an effort to counterbalance the pathological motor output. Significance Our results may help to understand the pathophysiology of sleep-related movement disorders in Huntington's Disease, and to define therapeutically strategies.
AB - Objective To evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD). Methods 23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA). Results In wake, HD patients showed an increase of delta lagged phase synchronization (T = 3.60; p < 0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4. In NREM, HD patients showed an increase of delta lagged phase synchronization (T = 3.56; p < 0.05) among left BA 1-2-3 and right BA 6-8. In REM, HD patients showed an increase of lagged phase synchronization (T = 3.60; p < 0.05) among the BA 6-8 bilaterally (delta band); left BA 1-2-3 and right BA 1-2-3 (theta); left BA 1-2-3 and right BA 4 (theta); left BA 1-2-3 and right BA 1-2-3 (alpha). Conclusions Our results may reflect an abnormal function of the motor areas or an effort to counterbalance the pathological motor output. Significance Our results may help to understand the pathophysiology of sleep-related movement disorders in Huntington's Disease, and to define therapeutically strategies.
KW - Brain
KW - EEG
KW - Electroencephalography
KW - Functional connectivity
KW - Humans
KW - Huntington Disease
KW - Huntington's Disease
KW - Nerve Net
KW - Neurology
KW - Neurology (clinical)
KW - Physiology (medical)
KW - Polysomnography
KW - Sensorimotor Cortex
KW - Sensory Systems
KW - Sensory-motor network
KW - Sleep
KW - Sleep Wake Disorders
KW - eLORETA
KW - Brain
KW - EEG
KW - Electroencephalography
KW - Functional connectivity
KW - Humans
KW - Huntington Disease
KW - Huntington's Disease
KW - Nerve Net
KW - Neurology
KW - Neurology (clinical)
KW - Physiology (medical)
KW - Polysomnography
KW - Sensorimotor Cortex
KW - Sensory Systems
KW - Sensory-motor network
KW - Sleep
KW - Sleep Wake Disorders
KW - eLORETA
UR - http://hdl.handle.net/10807/173603
UR - http://www.elsevier.com/inca/publications/store/6/0/1/5/2/8
U2 - 10.1016/j.clinph.2016.11.019
DO - 10.1016/j.clinph.2016.11.019
M3 - Article
SN - 1388-2457
VL - 128
SP - 1354
EP - 1363
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -