The aims of the study were: 1) to evaluate subjective sleep quality and daytime
sleepiness in patients affected by sporadic inclusion-body myositis (IBM); 2) to define the
sleep and sleep-related respiratory pattern in IBM patients.
Methods. Thirteen consecutive adult patients affected by definite IBM were enrolled, six
women and seven men, mean age 66.2±11.1 years (range: 50-80). Diagnosis was based on
clinical and muscle biopsy studies. All patients underwent subjective sleep evaluation
(Pittsburgh Sleep Quality Index, PSQI and Epworth Sleepiness Scale, ESS), oro-pharingoesophageal
scintigraphy, pulmonary function tests, psychometric measures, anatomic
evaluation of upper airways, and laboratory-based polysomnography. Findings in IBM
patients were compared to those obtained from a control group of 25 healthy subjects (13 men
and 12 women, mean age 61.9±8.6 years).
Results. Disease duration was >10 years in all. Mean IBM severity score was 28.8±5.4
(range 18-36). Dysphagia was present in 10 patients. Nine patients had PSQI scores ≥5;
patients had higher mean PSQI score (IBM: 7.2±4.7, Controls: 2.76±1.45, p=0.005); one
patient (and no controls) had EES >9. Polysomnography showed that IBM patients, compared to controls, had lower sleep efficiency (IBM: 78.8±12.0%, Controls: 94.0±4.5%, p<0.001),
more awakenings (IBM: 11.9±11.0, Controls: 5.2±7.5, p=0.009) and increased nocturnal time
awake (IBM: 121.2±82.0 min., Controls: 46.12±28.8 min., p=0.001). Seven Patients (and no
controls) had polysomnographic findings consistent with sleep disordered breathing (SDB).
Conclusions. Data suggest that sleep disruption, and in particular SDB, might be highly
prevalent in IBM.
Significance. Data indicate that IBM patients have poor sleep and high prevalence of SDB.
- sleep disordered breathing
- sporadic inclusion-body myositis