SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer

Stefano Gentileschi, Francesco Federico, Vincenzo Valentini, Alessandro Di Stefani, Ernesto Rossi, Giuseppe Ferdinando Colloca, Nicola Dinapoli, Carlotta Masciocchi, Jacopo Lenkowicz, Nikola Dino Capocchiano, Andrea Damiani, Gyorgy Kovacs, Luca Tagliaferri, Josè Luis Guinot, Agata Rembielak, Benjamin Guix, Artur Jan Chyrek, Arenas Meritxell, Silvia Rodriguez Villalba

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Purpose: The primary objective of the SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology is to define a specific terminological system to standardize data collection for non-melanoma skin cancer patients treated with brachytherapy (BT, interventional radiotherapy). Through ontological characterization of information, it is possible to find, isolate, organize, and integrate its meaning. Material and methods: SKIN-COBRA is a standardized data collection consortium for non-melanoma skin patients treated with BT, including 8 cancer centers. Its ontology was firstly defined by a multicentric and multidisciplinary working group and evaluated by the consortium, followed by a multi-professional technical commission involving a mathematician, an engineer, a physician with experience in data storage, a programmer, and a software expert. Results: Two hundred and ninety variables were defined in 10 input forms. There are 3 levels, with each offering a specific type of analysis: 1. Registry level (epidemiology analysis); 2. Procedures level (standard oncology analysis); 3. Research level (radiomics analysis). The ontology was approved by the technical commission and consortium, and an ad-hoc software system was defined to be implemented in the SKIN-COBRA consortium. Conclusions: Large databases are natural extension of traditional statistical approaches, a valuable and increasingly necessary tool for modern healthcare system. Future analysis of the collected multinational and multicenter data will show whether the use of the system can produce high-quality evidence to support multidisciplinary management of non-melanoma skin cancer and utilizing this information for personalized treatment decisions.
Lingua originaleEnglish
pagine (da-a)105-110
Numero di pagine6
RivistaJournal of Contemporary Brachytherapy
Volume12
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Brachytherapy
  • Ontology
  • Skin cancer

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