Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

E. Mazzone; F. Bianco; M. Main; M. Van Den Hauwe; M. Ash; R. De Vries; J. Fagoaga Mata; S. Stein; R. De Sanctis; A. D'Amico; C. Palermo; L. Fanelli; M. C. Scoto; A. Mayhew; M. Eagle; M. Vigo; A. Febrer; R. Korinthenberg; M. De Visser; K. Bushby; F. Muntoni; N. Goemans; M. P. Sormani; E. Bertini; M. Pane; Eugenio Maria Mercuri

doi:10.1016/j.nmd.2013.06.001

Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

E. Mazzone, F. Bianco, M. Main, M. Van Den Hauwe, M. Ash, R. De Vries, J. Fagoaga Mata, S. Stein, R. De Sanctis, A. D'Amico, C. Palermo, L. Fanelli, M. C. Scoto, A. Mayhew, M. Eagle, M. Vigo, A. Febrer, R. Korinthenberg, M. De Visser, K. BushbyF. Muntoni, N. Goemans, M. P. Sormani, E. Bertini, M. Pane, Eugenio Maria Mercuri

Risultato della ricerca: Contributo in rivista › Articolo in rivista

30 Citazioni (Scopus)

Abstract

The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.

Lingua originale	English
pagine (da-a)	624-628
Numero di pagine	5
Rivista	Neuromuscular disorders : NMD
Volume	23
DOI	https://doi.org/10.1016/j.nmd.2013.06.001
Stato di pubblicazione	Pubblicato - 2013

Keywords

6MWT
Outcome measures
Spinal muscular atrophy

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10.1016/j.nmd.2013.06.001

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Mazzone, E., Bianco, F., Main, M., Van Den Hauwe, M., Ash, M., De Vries, R., Fagoaga Mata, J., Stein, S., De Sanctis, R., D'Amico, A., Palermo, C., Fanelli, L., Scoto, M. C., Mayhew, A., Eagle, M., Vigo, M., Febrer, A., Korinthenberg, R., De Visser, M., ... Mercuri, E. M. (2013). Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study. Neuromuscular disorders : NMD, 23, 624-628. https://doi.org/10.1016/j.nmd.2013.06.001

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title = "Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study",

abstract = "The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.",

keywords = "6MWT, Outcome measures, Spinal muscular atrophy, 6MWT, Outcome measures, Spinal muscular atrophy",

author = "E. Mazzone and F. Bianco and M. Main and {Van Den Hauwe}, M. and M. Ash and {De Vries}, R. and {Fagoaga Mata}, J. and S. Stein and {De Sanctis}, R. and A. D'Amico and C. Palermo and L. Fanelli and Scoto, {M. C.} and A. Mayhew and M. Eagle and M. Vigo and A. Febrer and R. Korinthenberg and {De Visser}, M. and K. Bushby and F. Muntoni and N. Goemans and Sormani, {M. P.} and E. Bertini and M. Pane and Mercuri, {Eugenio Maria}",

year = "2013",

doi = "10.1016/j.nmd.2013.06.001",

language = "English",

volume = "23",

pages = "624--628",

journal = "Neuromuscular disorders : NMD",

}

Mazzone, E, Bianco, F, Main, M, Van Den Hauwe, M, Ash, M, De Vries, R, Fagoaga Mata, J, Stein, S, De Sanctis, R, D'Amico, A, Palermo, C, Fanelli, L, Scoto, MC, Mayhew, A, Eagle, M, Vigo, M, Febrer, A, Korinthenberg, R, De Visser, M, Bushby, K, Muntoni, F, Goemans, N, Sormani, MP, Bertini, E, Pane, M & Mercuri, EM 2013, 'Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study', Neuromuscular disorders : NMD, vol. 23, pagg. 624-628. https://doi.org/10.1016/j.nmd.2013.06.001

TY - JOUR

T1 - Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

AU - Mazzone, E.

AU - Bianco, F.

AU - Main, M.

AU - Van Den Hauwe, M.

AU - Ash, M.

AU - De Vries, R.

AU - Fagoaga Mata, J.

AU - Stein, S.

AU - De Sanctis, R.

AU - D'Amico, A.

AU - Palermo, C.

AU - Fanelli, L.

AU - Scoto, M. C.

AU - Mayhew, A.

AU - Eagle, M.

AU - Vigo, M.

AU - Febrer, A.

AU - Korinthenberg, R.

AU - De Visser, M.

AU - Bushby, K.

AU - Muntoni, F.

AU - Goemans, N.

AU - Sormani, M. P.

AU - Bertini, E.

AU - Pane, M.

AU - Mercuri, Eugenio Maria

PY - 2013

Y1 - 2013

N2 - The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.

AB - The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.

KW - 6MWT

KW - Outcome measures

KW - Spinal muscular atrophy

KW - 6MWT

KW - Outcome measures

KW - Spinal muscular atrophy

UR - http://hdl.handle.net/10807/53522

U2 - 10.1016/j.nmd.2013.06.001

DO - 10.1016/j.nmd.2013.06.001

M3 - Article

VL - 23

SP - 624

EP - 628

JO - Neuromuscular disorders : NMD

JF - Neuromuscular disorders : NMD

ER -

Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

Abstract

Keywords

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