Signalling by semaphorin receptors: Cell guidance and beyond

Luca Tamagnone*, Paolo M. Comoglio

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

284 Citazioni (Scopus)


Semaphorins are a large family of secreted or cell-bound signals, known to guide axons in developing nervous tissue. They are expressed in a variety of adult and embryonic tissues and are thought to have a broader spectrum of functions. Recent evidence suggests that semaphorins and their receptors play a key role in the control of cellular interactions, most likely in cell-cell repulsion. A subset of semaphorins interacts with neuropilins - cell-surface molecules lacking a signalling-competent cytoplasmic domain. Another large family of transmembrane molecules, namely plexins, bind specifically to semaphorins. Thus plexins, alone, or in association with neuropilins, behave as fully functional semaphorin receptors. The intracellular responses elicited by plexins are unknown, but their large cytoplasmic moiety, containing the strikingly conserved sex-plexin (SP) domain, is likely to trigger novel signal-transduction pathways. Copyright (C) 2000 Elsevier Science Ltd.
Lingua originaleEnglish
pagine (da-a)377-383
Numero di pagine7
RivistaTrends in Cell Biology
Stato di pubblicazionePubblicato - 2000




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