SIADH in a patient with sensory ataxic neuropathy with anti-disialosyl antibodies (CANOMAD)

CANOMAD (chronic ataxic neuropathy, opthalmoplegia, IgM paraprotein, cold agglutinins and disialosyl antibodies) is a rare variant of IgM paraproteinaemic neuropathy in which the paraprotein fraction contains antibodies against specific disialylated gangliosides, including GD1B, GD3, GT1B and GQ1B [1]. This disorder has so far not been reported in association with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here we describe a patient who developed SIADH during the first relapse of CANOMAD