Abstract
Abstract: Introduction: Lymph node status has become part of the new staging system for cervical
cancer (CC). It has been shown that patients staged as IIIC1 had heterogeneous prognoses and, in
some cases, experienced better outcomes than patients with lower stages. We evaluated the impact
of the number of metastatic pelvic lymph nodes (MPLNs) among patients with stage IIIC1 cervical
cancer. Methods: Survival analyses were conducted in order to identify the best cut-off prognostic
value relative to the number of MPLNs. Disease free survival (DFS) was considered the main
outcome. Results: 541 patients were included in the study. Eighty-nine patients were of stage IIIC1.
The best prognostic cut-off value of the number of MPLNs was 2. Patients with >2 MPLNs (n > 2
group) had worse DFS compared with those having <2 (N1-2 group) (5 yr DFS: 54.7% vs 78.1%, p
value = 0.006). Multivariate analyses demonstrated that the extent of MPLNs had little impact on
DFS and that replacement of IIIC1 staging with N1-2 and n > 2 grouping provided a better,
statistically significant model (p value = 0.006). Discussion: Using a cut-off value of 2, the number of
MPLNs could better predict prognostic outcomes within stage IIIC1 cervical cancer and have
potential implications for therapeutic decision-making in the treatment of patients with stage IIIC1
CC.
Lingua originale | English |
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pagine (da-a) | 1552-N/A |
Rivista | Cancers |
Volume | 12 |
DOI | |
Stato di pubblicazione | Pubblicato - 2020 |
Keywords
- FIGO
- IIIC
- cervical cancer
- cut-off
- lymph node
- number of lymph nodes
- number of metastatic lymph nodes
- staging system