Should EUS-guided tissue acquisition for histologic examination replace fine needle aspiration for cytologic examination? Another brick in the wall

Since its initial description in 1992 (1), endoscopic ultrasound-guided fine needle\r\naspiration (EUS-FNA) has become the procedure of choice to obtain samples to reach\r\nthe definitive diagnosis and proper lymph nodal staging of lesions of the gastrointestinal\r\n(GI) tract and of adjacent organs (2). The sensitivity of EUS-FNA, however, is\r\nstrongly dependent on the availability of an on-site cytopathology, which has been\r\nclearly demonstrated to significantly influence the diagnostic accuracy, as well as,\r\nthe proportions of indeterminate and unsatisfactory samples (3-5). Cytopathology,\r\nhowever, requires a high degree of expertise and unfortunately, the access to rapid\r\non-site cytopathology evaluation (ROSE) and the availability of a cytopathologist\r\nspecifically trained to interpret EUS specimens is not possible in many centers (6).\r\nThis has created a barrier to the dissemination of EUS in the community and in many\r\ncountries because the lack of cytology expertise results in a low diagnostic accuracy\r\nand therefore in a limited overall perceived utility of EUS (7,8).