Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study

Emanuele Marzetti, Francesco Landi, Roberto Bernabei, Graziano Onder, Maria Lorenzi, Manuela Antocicco, Michela Celi, Simona Mastropaolo, Silvana Settanni, Stefano Bonassi, Vanessa Valdiglesias

Risultato della ricerca: Contributo in rivistaArticolo in rivista

33 Citazioni (Scopus)

Abstract

Telomere shortening in peripheral blood mononuclear cells (PBMCs) has been associated with biological age and several chronic degenerative diseases. However, the relationship between telomere length and sarcopenia, a hallmark of the aging process, is unknown. The aim of the present study was therefore to determine whether PBMC telomeres obtained from sarcopenic older persons were shorter relative to non-sarcopenic peers. We further explored if PBMC telomere length was associated with frailty, a major clinical correlate of sarcopenia.
Lingua originaleEnglish
pagine (da-a)233-233
Numero di pagine1
RivistaFrontiers in Aging Neuroscience
Volume2014/6
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • bioelectrical impedance analysis
  • biological age
  • frailty
  • inflammation
  • muscle aging
  • oxidative stress

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