TY - JOUR
T1 - Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Preliminary analysis of a multicentre study
AU - Macrì, Antonio
AU - Arcoraci, Vincenzo
AU - Belgrano, Valerio
AU - Caldana, Marina
AU - Cioppa, Tommaso
AU - Costantini, Barbara
AU - Cucinotta, Eugenio
AU - De Cian, Franco
AU - De Iaco, Pierandrea
AU - De Manzoni, Giovanni
AU - Di Giorgio, Angelo
AU - Fleres, Francesco
AU - Muffatti, Francesca
AU - Orsenigo, Elena
AU - Daniele Pinna, Antonio
AU - Roviello, Franco
AU - Sammartino, Paolo
AU - Scambia, Giovanni
AU - Saladino, Edoardo
PY - 2014
Y1 - 2014
N2 - AIM:
To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.
PATIENTS AND METHODS:
A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.
RESULTS:
In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.
CONCLUSION:
Careful patient selection has to be performed to improve clinical outcomes
AB - AIM:
To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.
PATIENTS AND METHODS:
A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.
RESULTS:
In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.
CONCLUSION:
Careful patient selection has to be performed to improve clinical outcomes
KW - cytoreductive surgery
KW - ovarian cancer
KW - cytoreductive surgery
KW - ovarian cancer
UR - http://hdl.handle.net/10807/63286
UR - https://www.scopus.com/pages/publications/84917730465
M3 - Article
SN - 0250-7005
VL - 34
SP - 5689
EP - 5693
JO - Anticancer Research
JF - Anticancer Research
ER -
