Short-term and long-term outcomes after robot-assisted versus laparoscopic distal pancreatectomy for pancreatic neuroendocrine tumors (pNETs): a multicenter comparative study

Sergio Alfieri, Giovanni Butturini, Ugo Boggi, Andrea Pietrabissa, Luca Morelli, Fabio Vistoli, Isacco Damoli, Andrea Peri, Claudio Fiorillo, Luigi Pugliese, Marco Ramera, Nelide De Lio, Gregorio Di Franco, Alessandro Esposito, Alice Esposito, Luca Landoni, Fausto Rosa, Roberta Menghi, Giovanni Battista Doglietto, Giuseppe Quero

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Purpose: Minimally invasive surgery has increasingly gained popularity as a treatment of choice for pancreatectomy with encouraging initial results in robotic distal pancreatectomy (RDP). However, few data are available on the comparison between RDP and laparoscopic distal pancreatectomy (LDP) for pancreatic neuroendocrine tumors (pNETs). Our aim, thus, is to compare perioperative and long-term outcomes as well as total costs of RDP and LDP for pNETs. Methods: All RDPs and LDPs for pNETs performed in four referral centers from 2008 to 2016 were included. Perioperative outcomes, histopathological results, overall (OS) and disease-free survival (DFS), and total costs were evaluated. Results: Ninety-six RDPs and 85 LDPs were included. Demographic and clinical characteristics were comparable between the two cohorts. Operative time was 36.5 min longer in the RDP group (p = 0.009) but comparable to LDP after removing the docking time (247.9 vs 233.7 min; p = 0.6). LDP related to a lower spleen preservation rate (44.7% vs 65.3%; p < 0.0001) and higher blood loss (239.7 ± 112 vs 162.5 ± 98 cc; p < 0.0001). Advantages in operative time for RDP were documented in case of the spleen preservation procedures (265 ± 41.52 vs 291 ± 23 min; p = 0.04). Conversion rate, postoperative morbidity, and pancreatic fistula rate were similar between the two groups, as well as histopathological data, OS, and DFS. Significant advantages were evidenced for LDP regarding mean total costs (9235 (± 1935) € vs 11,226 (± 2365) €; p < 0.0001). Conclusions: Both RDP and LDP are safe and efficacious for pNETs treatment. However, RDP offers advantages with a higher spleen preservation rate and lower blood loss. Costs still remain the main limitation of the robotic approach.
Lingua originaleEnglish
pagine (da-a)459-468
Numero di pagine10
RivistaLangenbeck's Archives of Surgery
Volume404
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Aged
  • Female
  • Humans
  • Italy
  • Laparoscopy
  • Long-term outcomes
  • Male
  • Middle Aged
  • Minimally invasive
  • Neuroendocrine Tumors
  • Operative Time
  • Pancreatectomy
  • Pancreatic Neoplasms
  • Pancreatic neuroendocrine tumors
  • Retrospective Studies
  • Robot-assisted pancreatectomy
  • Robotic Surgical Procedures
  • Treatment Outcome

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