Short course accelerated radiation therapy (SHARON) in palliative treatment of advanced solid cancer in older patients: A pooled analysis

Vincenzo Valentini, Francesco Deodato, Gabriella Macchia, Luciana Caravatta, Francesco Cellini, Alessio Giuseppe Morganti, Eleonora Farina, Jenny Capuccini, Nam P. Nguyen, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Tigeneh Wondemagegnhu, A.F.M. Kamal Uddin, Mostafà Aziz Sumon, Domenico Genovesi, Milly Buwenge, Alessio G. Morganti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Objectives: To evaluate the efficacy and safety of a conformal Short Course Accelerated Radiation therapy (SHARON) for symptomatic palliation of locally advanced or metastatic cancers in older patients. Materials and Methods: This is a pooled analysis on patients aged ≥. 80 years selected between subjects enrolled in 3 phase I-II studies on a short course palliative treatment of advanced or metastatic cancer. The primary endpoint was to evaluate the symptoms response rate produced by accelerated radiotherapy delivered in 4 total fractions in twice a day. Total dose ranged between 14 Gy and 20 Gy while dose/fraction between 3.5 and 5 Gy. Results: A total of 48 patients were included in this analysis. Twenty-six patients (54.2%) had advanced primary or metastatic head and neck tumors, 11 (22.9%) locally advanced or metastatic thoracic cancers, 11 (22.9%) complicated bone metastases. The majority of patients presented pain (60.4%). With a median follow-up time of 5.5 months, no G4 acute and late toxicities were recorded. The overall palliative response rate was 91.7% with a median duration of palliation of 4 months. Conclusion: Short course accelerated radiotherapy in locally advanced or metastatic cancers is effective in terms of symptom relief and well tolerated even in older patients.
Lingua originaleEnglish
pagine (da-a)359-361
RivistaJournal of Geriatric Oncology
Volume9
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Older patients
  • Pain
  • Palliative care
  • Quality of life
  • Radiotherapy

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