Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection

Luciana Teofili; Maria Grazia Iachininoto; Sara Capodimonti; Eugenia Rosa Nuzzolo; Maurizio Martini; Maria Bianchi; Katia Falasca; Claudio Ucciferri; Francesca Vignale; Eligio Pizzigallo; Jacopo Vecchiet

doi:10.1089/AID.2012.0013

Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection

Luciana Teofili, Maria Grazia Iachininoto, Sara Capodimonti, Eugenia Rosa Nuzzolo, Maurizio Martini, Maria Bianchi, Katia Falasca, Claudio Ucciferri, Francesca Vignale, Eligio Pizzigallo, Jacopo Vecchiet

Risultato della ricerca: Contributo in rivista › Articolo in rivista

3 Citazioni (Scopus)

Abstract

Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.

Lingua originale	English
pagine (da-a)	307-310
Numero di pagine	4
Rivista	AIDS Research and Human Retroviruses
Volume	29
DOI	https://doi.org/10.1089/AID.2012.0013
Stato di pubblicazione	Pubblicato - 2013

Keywords

Endothelail progenitors
HIV

Accesso al documento

10.1089/AID.2012.0013

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title = "Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection",

abstract = "Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.",

keywords = "Endothelail progenitors, HIV, Endothelail progenitors, HIV",

author = "Luciana Teofili and Iachininoto, {Maria Grazia} and Sara Capodimonti and Nuzzolo, {Eugenia Rosa} and Maurizio Martini and Maria Bianchi and Katia Falasca and Claudio Ucciferri and Francesca Vignale and Eligio Pizzigallo and Jacopo Vecchiet",

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doi = "10.1089/AID.2012.0013",

language = "English",

volume = "29",

pages = "307--310",

journal = "AIDS Research and Human Retroviruses",

issn = "0889-2229",

publisher = "Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688",

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TY - JOUR

T1 - Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection

AU - Teofili, Luciana

AU - Iachininoto, Maria Grazia

AU - Capodimonti, Sara

AU - Nuzzolo, Eugenia Rosa

AU - Martini, Maurizio

AU - Bianchi, Maria

AU - Falasca, Katia

AU - Ucciferri, Claudio

AU - Vignale, Francesca

AU - Pizzigallo, Eligio

AU - Vecchiet, Jacopo

PY - 2013

Y1 - 2013

N2 - Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.

AB - Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.

KW - Endothelail progenitors

KW - HIV

KW - Endothelail progenitors

KW - HIV

UR - http://hdl.handle.net/10807/40574

U2 - 10.1089/AID.2012.0013

DO - 10.1089/AID.2012.0013

M3 - Article

VL - 29

SP - 307

EP - 310

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

ER -

Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection

Abstract

Keywords

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