TY - JOUR
T1 - Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection
AU - Falasca, Katia
AU - Ucciferri, Claudio
AU - Teofili, Luciana
AU - Iachininoto, Maria Grazia
AU - Capodimonti, Sara
AU - Nuzzolo, Eugenia Rosa
AU - Martini, Maurizio
AU - Bianchi, Maria
AU - Vignale, Francesca
AU - Pizzigallo, Eligio
AU - Vecchiet, Jacopo
PY - 2013
Y1 - 2013
N2 - Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.
AB - Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.
KW - Endothelail progenitors
KW - HIV
KW - Endothelail progenitors
KW - HIV
UR - http://hdl.handle.net/10807/40574
U2 - 10.1089/AID.2012.0013
DO - 10.1089/AID.2012.0013
M3 - Article
SN - 0889-2229
VL - 29
SP - 307
EP - 310
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
ER -
