TY - JOUR
T1 - Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
AU - Fusco, William
AU - Lorenzo, Manuel Bernabeu
AU - Cintoni, Marco
AU - Porcari, Serena
AU - Rinninella, Emanuele
AU - Kaitsas, Francesco
AU - Lener, Elena
AU - Mele, Maria Cristina
AU - Gasbarrini, Antonio
AU - Collado, Maria Carmen
AU - Cammarota, Giovanni
AU - Ianiro, Gianluca
PY - 2023
Y1 - 2023
N2 - Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs' roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs. Moreover, we will describe the potential therapeutic approaches to boost the levels of SCFAs in the human gut and treat different related diseases.
AB - Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs' roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs. Moreover, we will describe the potential therapeutic approaches to boost the levels of SCFAs in the human gut and treat different related diseases.
KW - SCFA-producing bacteria
KW - diet
KW - gut health
KW - short-chain fatty acids
KW - prebiotics
KW - probiotics
KW - gut microbiota
KW - SCFA-producing bacteria
KW - diet
KW - gut health
KW - short-chain fatty acids
KW - prebiotics
KW - probiotics
KW - gut microbiota
UR - http://hdl.handle.net/10807/247757
U2 - 10.3390/nu15092211
DO - 10.3390/nu15092211
M3 - Article
SN - 2072-6643
VL - 15
SP - 2211-N/A
JO - Nutrients
JF - Nutrients
ER -
