TY - JOUR
T1 - Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology
AU - De Angelis, Rossella
AU - Giuggioli, Dilia
AU - Bajocchi, Gianluigi
AU - Dagna, Lorenzo
AU - Zanframundo, Giovanni
AU - Foti, Rosario
AU - Cacciapaglia, Fabio
AU - Cuomo, Giovanna
AU - Ariani, Alarico
AU - Rosato, Edoardo
AU - Guiducci, Serena
AU - Girelli, Francesco
AU - Riccieri, Valeria
AU - Zanatta, Elisabetta
AU - Bosello, Silvia Laura
AU - Cavazzana, Ilaria
AU - Ingegnoli, Francesca
AU - Murdaca, Giuseppe
AU - Abignano, Giuseppina
AU - Romeo, Nicoletta
AU - Rossa, Alessandra Della
AU - Caminiti, Maurizio
AU - Iuliano, Annamaria
AU - Ciano, Giovanni
AU - Beretta, Lorenzo
AU - Bagnato, Gianluca
AU - Lubrano, Ennio
AU - De Andres, Ilenia
AU - Giollo, Alessandro
AU - Saracco, Marta
AU - Agnes, Cecilia
AU - Lumetti, Federica
AU - Spinella, Amelia
AU - Magnani, Luca
AU - Campochiaro, Corrado
AU - De Luca, Giacomo
AU - Codullo, Veronica
AU - Visalli, Elisa
AU - Masini, Francesco
AU - Gigante, Antonietta
AU - Bellando-Randone, Silvia
AU - Pellegrino, Greta
AU - Pigatto, Erika
AU - Dall’Ara, Francesca
AU - Lazzaroni, Maria Grazia
AU - Generali, Elena
AU - Mennillo, Gianna
AU - Barsotti, Simone
AU - Mariano, Giuseppa Pagano
AU - Calabrese, Francesca
AU - Furini, Federica
AU - Vultaggio, Licia
AU - Parisi, Simone
AU - Peroni, Clara Lisa
AU - Risa, Anna Maria
AU - Rozza, Davide
AU - Zanetti, Anna
AU - Carrara, Greta
AU - Landolfi, Giampiero
AU - Scirè, Carlo Alberto
AU - Bianchi, Gerolamo
AU - Fusaro, Enrico
AU - Sebastiani, Gian Domenico
AU - Govoni, Marcello
AU - D’Angelo, Salvatore
AU - D'Angelo, Salvatore
AU - Cozzi, Franco
AU - Doria, Andrea
AU - Iannone, Florenzo
AU - Salvarani, Carlo
AU - Matucci-Cerinic, Marco
AU - Ferri, Clodoveo
PY - 2022
Y1 - 2022
N2 - Objective. There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.Methods. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.Results. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.Conclusion. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.
AB - Objective. There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.Methods. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.Results. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.Conclusion. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.
KW - scleroderma
KW - sex
KW - systemic sclerosis
KW - scleroderma
KW - sex
KW - systemic sclerosis
UR - http://hdl.handle.net/10807/237734
U2 - 10.3899/jrheum.210794
DO - 10.3899/jrheum.210794
M3 - Article
SN - 0315-162X
VL - 49
SP - 176
EP - 185
JO - THE JOURNAL OF RHEUMATOLOGY
JF - THE JOURNAL OF RHEUMATOLOGY
ER -