Severe sepsis in a premature neonate: protein C replacement therapy

Maria Pia De Carolis; Valentina Polimeni; Patrizia Papacci; Serafina Lacerenza; Costantino Romagnoli

Severe sepsis in a premature neonate: protein C replacement therapy

Maria Pia De Carolis, Valentina Polimeni, Patrizia Papacci, Serafina Lacerenza, Costantino Romagnoli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.

Lingua originale	English
pagine (da-a)	405-408
Numero di pagine	4
Rivista	Turkish Journal of Pediatrics
Stato di pubblicazione	Pubblicato - 2008

Keywords

neonate
sepsis

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title = "Severe sepsis in a premature neonate: protein C replacement therapy",

abstract = "Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.",

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T1 - Severe sepsis in a premature neonate: protein C replacement therapy

AU - De Carolis, Maria Pia

AU - Polimeni, Valentina

AU - Papacci, Patrizia

AU - Lacerenza, Serafina

AU - Romagnoli, Costantino

PY - 2008

Y1 - 2008

N2 - Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.

AB - Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.

KW - neonate

KW - sepsis

KW - neonate

KW - sepsis

UR - http://hdl.handle.net/10807/25010

M3 - Article

SN - 0041-4301

SP - 405

EP - 408

JO - Turkish Journal of Pediatrics

JF - Turkish Journal of Pediatrics

ER -

Severe sepsis in a premature neonate: protein C replacement therapy

Abstract

Keywords

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