TY - JOUR
T1 - Severe sepsis in a premature neoante: protein C replacemnet therapy
AU - De Carolis, Maria Pia
AU - Polimeni, Valentina
AU - Papacci, Patrizia
AU - Lacerenza, Serafina
AU - Romagnoli, Costantino
PY - 2008
Y1 - 2008
N2 - Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
AB - Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
KW - Severe spepsis premature neonate
KW - protein C
KW - Severe spepsis premature neonate
KW - protein C
UR - http://hdl.handle.net/10807/22906
M3 - Article
SN - 0022-3476
SP - 405
EP - 408
JO - THE JOURNAL OF PEDIATRICS
JF - THE JOURNAL OF PEDIATRICS
ER -