Severe hypocholesterolemia in surgical patients, sepsis, and critical illness.

Carlo Chiarla, Ivo Giovannini, Felice Giuliante, Zdenek Zadak, Maria Vellone, Francesco Ardito, Gennaro Clemente, Marino Murazio, Gennaro Nuzzo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

37 Citazioni (Scopus)


After surgery, in sepsis and various critical illnesses, factors such as severity of the acute phase response, liver dysfunction, and hemodilution from blood loss have cumulative impacts in decreasing cholesterol; therefore, degree of hypocholesterolemia often reflects severity of illness. The direct correlation between cholesterol and several plasma proteins is mediated by the parallel impact of commonly shared determinants. Cholestasis is associated with a moderation of the degree of hypocholesterolemia. In human sepsis, the poor implications of hypocholesterolemia seem to be aggravated by the simultaneous development of hypertriglyceridemia. Cholesterol and triglyceride levels reflect altered lipoprotein patterns, and the issue is too complex and too poorly understood to be reduced to simple concepts; nevertheless, these simple measurements often represent helpful adjunctive clinical tools.
Lingua originaleEnglish
pagine (da-a)36107-36112
Numero di pagine6
RivistaJournal of Critical Care
Stato di pubblicazionePubblicato - 2010


  • Critical illness
  • Hypocholesterolemia
  • Plasma cholesterol
  • Plasma triglycerides
  • Sepsis
  • Surgery
  • Trauma


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