TY - JOUR
T1 - Severe Hyperleukocytosis and multifocal intracranial haemorrhage: not always a fatal outcome.
AU - Ruggiero, Antonio
AU - Attinà, G.
AU - Piastra, Marco
AU - Maurizi, Palma
AU - Mastrangelo, Stefano
AU - Pietrini, Domenico
AU - Riccardi, Riccardo
PY - 2009
Y1 - 2009
N2 - Severe hyperleukocytosis caused by acute lymphoblastic leukaemia (ALL) is associated with an increased risk of early death due to the intracranial haemorrhage. We report on a boy who presented with ALL with an extremely high leukocyte count, who developed neurological deterioration due to multiple intracerebral haemorrhages. Adequate measures for managing this medical emergency include appropriate supportive measures and initiation of therapy to prevent symptoms of leukostasis. Aggressive measures as a decompressive craniectomy should be considered to improve the poor outcome observed in this subset of patients
AB - Severe hyperleukocytosis caused by acute lymphoblastic leukaemia (ALL) is associated with an increased risk of early death due to the intracranial haemorrhage. We report on a boy who presented with ALL with an extremely high leukocyte count, who developed neurological deterioration due to multiple intracerebral haemorrhages. Adequate measures for managing this medical emergency include appropriate supportive measures and initiation of therapy to prevent symptoms of leukostasis. Aggressive measures as a decompressive craniectomy should be considered to improve the poor outcome observed in this subset of patients
KW - hyperleukocytosis
KW - intracranial hemorrhage
KW - hyperleukocytosis
KW - intracranial hemorrhage
UR - http://hdl.handle.net/10807/16874
U2 - 10.1007/s12185-009-0333-2
DO - 10.1007/s12185-009-0333-2
M3 - Article
SN - 0925-5710
VL - 90
SP - 87
EP - 90
JO - International Journal of Hematology
JF - International Journal of Hematology
ER -