Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

Mario Rotondi; Anna Paola Batocchi; Francesca Coperchini; Marcella Caggiula; Francesca Zerbini; Riccardo Sideri; Paola Leporati; Viviana Nociti; Giovanni Frisullo; Massimiliano Mirabella; Flavia Magri; Antonio Oliviero; Luca Chiovato

doi:10.1159/000353567

Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

Mario Rotondi, Anna Paola Batocchi, Francesca Coperchini, Marcella Caggiula, Francesca Zerbini, Riccardo Sideri, Paola Leporati, Viviana Nociti, Giovanni Frisullo, Massimiliano Mirabella, Flavia Magri, Antonio Oliviero, Luca Chiovato

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

18 Citazioni (Scopus)

Abstract

Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

Lingua originale	English
pagine (da-a)	341-347
Numero di pagine	7
Rivista	NeuroImmunoModulation
Volume	20
DOI	https://doi.org/10.1159/000353567
Stato di pubblicazione	Pubblicato - 2013

Keywords

Adolescent
Adult
Aged
Body Mass Index
Disability Evaluation
Female
Humans
Leptin
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Severity of Illness Index
Young Adult

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Rotondi, M., Batocchi, A. P., Coperchini, F., Caggiula, M., Zerbini, F., Sideri, R., Leporati, P., Nociti, V., Frisullo, G., Mirabella, M., Magri, F., Oliviero, A., & Chiovato, L. (2013). Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion. NeuroImmunoModulation, 20, 341-347. https://doi.org/10.1159/000353567

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title = "Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion",

abstract = "Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.",

keywords = "Adolescent, Adult, Aged, Body Mass Index, Disability Evaluation, Female, Humans, Leptin, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Young Adult, Adolescent, Adult, Aged, Body Mass Index, Disability Evaluation, Female, Humans, Leptin, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Young Adult",

author = "Mario Rotondi and Batocchi, {Anna Paola} and Francesca Coperchini and Marcella Caggiula and Francesca Zerbini and Riccardo Sideri and Paola Leporati and Viviana Nociti and Giovanni Frisullo and Massimiliano Mirabella and Flavia Magri and Antonio Oliviero and Luca Chiovato",

year = "2013",

doi = "10.1159/000353567",

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journal = "NeuroImmunoModulation",

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Rotondi, M, Batocchi, AP, Coperchini, F, Caggiula, M, Zerbini, F, Sideri, R, Leporati, P, Nociti, V, Frisullo, G, Mirabella, M, Magri, F, Oliviero, A & Chiovato, L 2013, 'Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion', NeuroImmunoModulation, vol. 20, pagg. 341-347. https://doi.org/10.1159/000353567

TY - JOUR

T1 - Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

AU - Rotondi, Mario

AU - Batocchi, Anna Paola

AU - Coperchini, Francesca

AU - Caggiula, Marcella

AU - Zerbini, Francesca

AU - Sideri, Riccardo

AU - Leporati, Paola

AU - Nociti, Viviana

AU - Frisullo, Giovanni

AU - Mirabella, Massimiliano

AU - Magri, Flavia

AU - Oliviero, Antonio

AU - Chiovato, Luca

PY - 2013

Y1 - 2013

N2 - Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

AB - Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

KW - Adolescent

KW - Adult

KW - Aged

KW - Body Mass Index

KW - Disability Evaluation

KW - Female

KW - Humans

KW - Leptin

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Severity of Illness Index

KW - Young Adult

KW - Adolescent

KW - Adult

KW - Aged

KW - Body Mass Index

KW - Disability Evaluation

KW - Female

KW - Humans

KW - Leptin

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Severity of Illness Index

KW - Young Adult

UR - http://hdl.handle.net/10807/62759

U2 - 10.1159/000353567

DO - 10.1159/000353567

M3 - Article

SN - 1021-7401

VL - 20

SP - 341

EP - 347

JO - NeuroImmunoModulation

JF - NeuroImmunoModulation

ER -

Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

Abstract

Keywords

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