Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

Massimiliano Mirabella, Anna Paola Batocchi, Marcella Caggiula, Viviana Nociti, Giovanni Frisullo, Mario Rotondi, Francesca Coperchini, Francesca Zerbini, Riccardo Sideri, Paola Leporati, Flavia Magri, Antonio Oliviero, Luca Chiovato

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

17 Citazioni (Scopus)

Abstract

Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.
Lingua originaleEnglish
pagine (da-a)341-347
Numero di pagine7
RivistaNeuroImmunoModulation
Volume20
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adolescent
  • Adult
  • Aged
  • Body Mass Index
  • Disability Evaluation
  • Female
  • Humans
  • Leptin
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting
  • Severity of Illness Index
  • Young Adult

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