Serum protein profiling of early and advanced stage Crohn's disease

Viviana Greco, C. Piras, A. Soggiu, A. Cassinotti, G. Maconi, S. Ardizzone, A. Amoresano, G. Bianchi Porro, L. Bonizzi, P. Roncada

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

Crohn's disease (CD) represents a highly debilitating disease of difficult diagnosis and increasing incidence. Serum protein profiling of early stage Crohn's disease (ES) CD was investigated in order to improve the comprehension of the very early pathologic mechanisms and to support the difficult diagnostic procedures currently available. Inflammatory proteins and complement 3 chain C (C3c) were over-represented during ES CD, clusterin, retinol binding protein, α1-microglobulin and transthyretin were under-represented. A C3c isoform was found to be present only during ES CD. By now, lack of specific antibodies to detect isoforms made it impossible to perform alternative validation. © 2014 The Authors.
Lingua originaleEnglish
pagine (da-a)48-59
Numero di pagine12
RivistaEuPA Open Proteomics
Volume3
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • 2D electrophoresis
  • C3c complement
  • Comparative proteomics
  • Crohn's disease
  • Transthyretin

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