Serum metabolic profile in multiple sclerosis patients

Barbara Tavazzi, Anna Paola Batocchi, Angela Maria Amorini, Giuseppe Lazzarino

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established. Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions. According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric acid undergoes to decrease, increase, or no change under this pathological condition. In this study, we report the serum metabolic profile in terms of purines, pyrimidines, creatinine, malondialdehyde, ascorbic acid, nitrite, and nitrate in a group of 170 MS patients. The results show increase in circulating uric acid and other oxypurines (hypoxanthine and xanthine), as well as in uridine and β-pseudouridine. The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid, demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.
Lingua originaleEnglish
pagine (da-a)167156-167162
Numero di pagine7
RivistaMultiple Sclerosis
Stato di pubblicazionePubblicato - 2011

Keywords

  • energy metabolism
  • multiple sclerosis
  • uric acid

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