Serum lactate as a novel potential biomarker in multiple sclerosis

Barbara Tavazzi, Angela Maria Amorini, Viviana Nociti, Giacomo Lazzarino, Valentina Di Pietro, Giuseppe Lazzarino, Angela M. Amorini, Axel Petzold, Claudio Gasperini, Esmeralda Quartuccio, Antonio Belli, Stefano Signoretti, Roberto Vagnozzi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

53 Citazioni (Scopus)

Abstract

Multiple sclerosis (MS) is a primary inflammatory demyelinating disease associated with a probably secondary progressive neuronegenerative component. Impaired mitochondrial functioning has been hypothesised to drive neurodegeneration and to cause increased anaerobic metabolism in MS. The aim of our multicentre study was to determine whether MS patients had values of circulating lactate different from those of controls. Patients (n=613) were recruited, assessed for disability and clinically classified (relapling-remitting, secondary progressive, primary progressive) at the Catholic University of Rome, Italy (n=281), at the MS Centre Amsterdam, The Netherlands (n=158) and at the S. Camillo Forlanini Hospital, Rome, Italy (n=174). Serum lactate levels were quantified spectrophotometrically with the analyst being blinded to all clinical information. In patients with MS serum lactate was three times higher (3.04±1.26mmol/l) than that of healthy controls (1.09±0.25mmol/l, p<0.0001) and increased across clinical groups, with higher levels in cases with a progressive than with a relapsing-remitting disease course. In addition, there was a linear correlation between serum lactate levels and the EDSS (R2=0.419; p<0.001). These data support the hypothesis that mitochondrial dysfunction is an important feature in MS and of particular relevance to the neurodegenerative phase of the disease. Measurement of serum lactate in MS might be a relative inexpensive test for longitudinal monitoring of "virtual hypoxia" in MS. and also a secondary outcome for treatment trials aimed to improve mitochondrial function in patients with MS.
Lingua originaleEnglish
pagine (da-a)1-7
Numero di pagine7
RivistaBIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • biomarker
  • lactate
  • multiple sclerosis
  • serum

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