Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Jwm Nin; I Ferreira; Cg Schalkwijk; Mh Prins; N Chaturvedi; Jh Fuller; Cda Stehouwer; Eurodiab Prospective Complication Study; Angelo Maria Minnella

doi:10.1530/EJE-11-0662

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Jwm Nin^*
, I Ferreira
, Cg Schalkwijk
, Mh Prins
, N Chaturvedi
, Jh Fuller
, Cda Stehouwer
, Eurodiab Prospective Complication Study
, Angelo Maria Minnella

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

10 Citazioni (SciVal)

Abstract

High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.

Lingua originale	Inglese
pagine (da-a)	325-332
Numero di pagine	8
Rivista	European Journal of Endocrinology
Volume	166
Numero di pubblicazione	2
DOI	https://doi.org/10.1530/EJE-11-0662
Stato di pubblicazione	Pubblicato - 2012

OSS delle Nazioni Unite

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SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Endocrinologia, Diabete e Metabolismo
Endocrinologia

Keywords

Adult
Albuminuria
Biological Markers
Cardiovascular Diseases
Case-Control Studies
Cross-Sectional Studies
Diabetes Complications
Diabetes Mellitus
Europe
Female
Glomerular Filtration Rate
HMGB1 Protein
Humans
Male
Middle Aged
Risk Factors
Severity of Illness Index
Type 1

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10.1530/EJE-11-0662

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Nin, J., Ferreira, I., Schalkwijk, C., Prins, M., Chaturvedi, N., Fuller, J., Stehouwer, C., Study, E. P. C., & Minnella, A. M. (2012). Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study. European Journal of Endocrinology, 166(2), 325-332. https://doi.org/10.1530/EJE-11-0662

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abstract = "High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.",

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author = "Jwm Nin and I Ferreira and Cg Schalkwijk and Mh Prins and N Chaturvedi and Jh Fuller and Cda Stehouwer and Study, \{Eurodiab Prospective Complication\} and Minnella, \{Angelo Maria\}",

year = "2012",

doi = "10.1530/EJE-11-0662",

language = "English",

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Nin, J, Ferreira, I, Schalkwijk, C, Prins, M, Chaturvedi, N, Fuller, J, Stehouwer, C, Study, EPC & Minnella, AM 2012, 'Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study', European Journal of Endocrinology, vol. 166, n. 2, pagg. 325-332. https://doi.org/10.1530/EJE-11-0662

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study. / Nin, Jwm; Ferreira, I; Schalkwijk, Cg et al.
In: European Journal of Endocrinology, Vol. 166, N. 2, 2012, pag. 325-332.

Risultato della ricerca: Contributo in rivista › Articolo

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ER -

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Abstract

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All Science Journal Classification (ASJC) codes

Keywords

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