Serum-Circulating microRNAs in Sporadic Inclusion Body Myositis

Matteo Lucchini, Valeria De Arcangelis, Massimo Santoro, Roberta Morosetti, Aldobrando Broccolini, Massimiliano Mirabella

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Sporadic inclusion body myositis (s-IBM) represents a unique disease within idiopathic inflammatory myopathies with a dual myodegenerative-autoimmune physiopathology and a lack of an efficacious treatment. Circulating miRNA expression could expand our knowledge of s-IBM patho-mechanisms and provide new potential disease biomarkers. To evaluate the expression of selected pre-amplified miRNAs in the serum of s-IBM patients compared to those of a sex- and age-matched healthy control group, we enrolled 14 consecutive s-IBM patients and 8 sex- and age-matched healthy controls. By using two different normalization approaches, we found one downregulated and three upregulated miRNAs. hsa-miR-192-5p was significantly downregulated, while hsa-miR-372-3p was found to be upregulated more in the s-IBM patients compared to the level of the controls. The other two miRNAs had a very low expression levels (raw Ct data > 29). hsa-miR-192-5p and hsa-miR-372-3p were found to be significantly dysregulated in the serum of s-IBM patients. These miRNAs are involved in differentiation and regeneration processes, thus possibly reflecting pathological mechanisms in s-IBM muscles and potentially representing disease biomarkers.
Lingua originaleEnglish
pagine (da-a)11139-N/A
RivistaInternational Journal of Molecular Sciences
Volume24
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • hsa-miR-192-5p
  • hsa-miR-372-3p
  • idiopathic inflammatory myopathy
  • inclusion body myositis
  • miRNA

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