Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment

Giorgio Attina; Silvia Triarico; Alberto Romano; Palma Maurizi; Stefano Mastrangelo; Antonio Ruggiero

doi:10.13005/bpj/2468

Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment

Giorgio Attina, Silvia Triarico, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Antonio Ruggiero

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to congestive heart failure for long-term survivors years after treatment. Currently, echocardiography is used to control the heart function during anthracyclines therapy. B-type natriuretic peptide (BNP) and NT-proBNP as well as cardiac troponins have been proposed as clinical markers for subclinical anthracycline-induced cardiotoxicity. The BNP and pro-BNP can be easily measured in plasma and initial data indicate that the NT-proBNP could be sensitive predictor for the development of congestive heart failure.

Lingua originale	English
pagine (da-a)	1311-1321
Numero di pagine	11
Rivista	BIOMEDICAL & PHARMACOLOGY JOURNAL
Volume	15
DOI	https://doi.org/10.13005/bpj/2468
Stato di pubblicazione	Pubblicato - 2022

Keywords

Anthracyclines
Troponin
pro-BNP
Children

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title = "Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment",

abstract = "Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to congestive heart failure for long-term survivors years after treatment. Currently, echocardiography is used to control the heart function during anthracyclines therapy. B-type natriuretic peptide (BNP) and NT-proBNP as well as cardiac troponins have been proposed as clinical markers for subclinical anthracycline-induced cardiotoxicity. The BNP and pro-BNP can be easily measured in plasma and initial data indicate that the NT-proBNP could be sensitive predictor for the development of congestive heart failure.",

keywords = "Anthracyclines, Troponin, pro-BNP, Children, Anthracyclines, Troponin, pro-BNP, Children",

author = "Giorgio Attina and Silvia Triarico and Alberto Romano and Palma Maurizi and Stefano Mastrangelo and Antonio Ruggiero",

year = "2022",

doi = "10.13005/bpj/2468",

language = "English",

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TY - JOUR

T1 - Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment

AU - Attina, Giorgio

AU - Triarico, Silvia

AU - Romano, Alberto

AU - Maurizi, Palma

AU - Mastrangelo, Stefano

AU - Ruggiero, Antonio

PY - 2022

Y1 - 2022

N2 - Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to congestive heart failure for long-term survivors years after treatment. Currently, echocardiography is used to control the heart function during anthracyclines therapy. B-type natriuretic peptide (BNP) and NT-proBNP as well as cardiac troponins have been proposed as clinical markers for subclinical anthracycline-induced cardiotoxicity. The BNP and pro-BNP can be easily measured in plasma and initial data indicate that the NT-proBNP could be sensitive predictor for the development of congestive heart failure.

AB - Anthracyclines are routinely used in cancer chemotherapy in many childhood cancers. A serious adverse effect of doxorubicin chemotherapy is cardiotoxicity which may lead to congestive heart failure for long-term survivors years after treatment. Currently, echocardiography is used to control the heart function during anthracyclines therapy. B-type natriuretic peptide (BNP) and NT-proBNP as well as cardiac troponins have been proposed as clinical markers for subclinical anthracycline-induced cardiotoxicity. The BNP and pro-BNP can be easily measured in plasma and initial data indicate that the NT-proBNP could be sensitive predictor for the development of congestive heart failure.

KW - Anthracyclines

KW - Troponin

KW - pro-BNP

KW - Children

KW - Anthracyclines

KW - Troponin

KW - pro-BNP

KW - Children

UR - http://hdl.handle.net/10807/297730

U2 - 10.13005/bpj/2468

DO - 10.13005/bpj/2468

M3 - Article

SN - 0974-6242

VL - 15

SP - 1311

EP - 1321

JO - BIOMEDICAL & PHARMACOLOGY JOURNAL

JF - BIOMEDICAL & PHARMACOLOGY JOURNAL

ER -

Serum Biomarkers for the Detection of Cardiac Dysfunction in Childhood Cancers Receiving Anthracycline-Based Treatment

Abstract

Keywords

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