Serum amyloid-A in Behçet's disease.

Antonio Vitale; Donato Rigante; Giuseppe Lopalco; Maria Giuseppina Brizi; Francesco Caso; Rossella Franceschini; Rosario Denaro; Mauro Galeazzi; Leonardo Punzi; Florenzo Iannone; Giovanni Lapadula; Antonella Simpatico; Edoardo Marrani; Luisa Costa; Rolando Cimaz; Luca Cantarini

doi:10.1007/s10067-014-2555-9

Serum amyloid-A in Behçet's disease.

Antonio Vitale, Donato Rigante, Giuseppe Lopalco, Maria Giuseppina Brizi, Francesco Caso, Rossella Franceschini, Rosario Denaro, Mauro Galeazzi, Leonardo Punzi, Florenzo Iannone, Giovanni Lapadula, Antonella Simpatico, Edoardo Marrani, Luisa Costa, Rolando Cimaz, Luca Cantarini

Risultato della ricerca: Contributo in rivista › Articolo in rivista

14 Citazioni (Scopus)

Abstract

Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Behçet’s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.

Lingua originale	English
pagine (da-a)	1165-1167
Numero di pagine	3
Rivista	Clinical Rheumatology
Volume	33
DOI	https://doi.org/10.1007/s10067-014-2555-9
Stato di pubblicazione	Pubblicato - 2014

Keywords

Behçet's disease
Serum amyloid-A

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10.1007/s10067-014-2555-9

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title = "Serum amyloid-A in Beh{\c c}et's disease.",

abstract = "Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Beh{\c c}et{\textquoteright}s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.",

keywords = "Beh{\c c}et's disease, Serum amyloid-A, Beh{\c c}et's disease, Serum amyloid-A",

author = "Antonio Vitale and Donato Rigante and Giuseppe Lopalco and Brizi, {Maria Giuseppina} and Francesco Caso and Rossella Franceschini and Rosario Denaro and Mauro Galeazzi and Leonardo Punzi and Florenzo Iannone and Giovanni Lapadula and Antonella Simpatico and Edoardo Marrani and Luisa Costa and Rolando Cimaz and Luca Cantarini",

year = "2014",

doi = "10.1007/s10067-014-2555-9",

language = "English",

volume = "33",

pages = "1165--1167",

journal = "Clinical Rheumatology",

issn = "0770-3198",

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TY - JOUR

T1 - Serum amyloid-A in Behçet's disease.

AU - Vitale, Antonio

AU - Rigante, Donato

AU - Lopalco, Giuseppe

AU - Brizi, Maria Giuseppina

AU - Caso, Francesco

AU - Franceschini, Rossella

AU - Denaro, Rosario

AU - Galeazzi, Mauro

AU - Punzi, Leonardo

AU - Iannone, Florenzo

AU - Lapadula, Giovanni

AU - Simpatico, Antonella

AU - Marrani, Edoardo

AU - Costa, Luisa

AU - Cimaz, Rolando

AU - Cantarini, Luca

PY - 2014

Y1 - 2014

N2 - Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Behçet’s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.

AB - Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Behçet’s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.

KW - Behçet's disease

KW - Serum amyloid-A

KW - Behçet's disease

KW - Serum amyloid-A

UR - http://hdl.handle.net/10807/62937

U2 - 10.1007/s10067-014-2555-9

DO - 10.1007/s10067-014-2555-9

M3 - Article

SN - 0770-3198

VL - 33

SP - 1165

EP - 1167

JO - Clinical Rheumatology

JF - Clinical Rheumatology

ER -

Serum amyloid-A in Behçet's disease.

Abstract

Keywords

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