Serotonin Transporter Gene (SLC6A4) Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants

Federica Morandi, Livio Provenzi, Marco Fumagalli, Renato Borgatti, Rosario Montirosso, Monica Fumagalli, Ida Sirgiovanni, Roberto Giorda, Uberto Pozzoli, Silvana Beri, Giorgia Menozzi, Ed Tronick, Francesco Morandi, Fabio Mosca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

50 Citazioni (Scopus)

Abstract

Preterm birth and Neonatal Intensive Care Unit (NICU) stay are early adverse stressful experiences, which may result in an altered temperamental profile. The serotonin transporter gene (SLC6A4), which has been linked to infant temperament, is susceptible to epigenetic regulation associated with early stressful experience. This study examined a moderation model in which the exposure to NICU-related stress and SLC6A4 methylation moderated infant temperament at 3 months of age. SLC6A4 methylation at 20 CpG sites was quantified in preterm infants (N = 48) and full-term infants (N = 30) from Italian middle-class families. Results suggested that in preterm infants NICU-related stress might be associated with alterations of serotonergic tone as a consequence of SLC6A4 methylation, which in turn, might associate with temperamental difficulties assessed at 3 months of age.
Lingua originaleEnglish
pagine (da-a)38-48
Numero di pagine11
RivistaChild Development
Volume87
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Serotonin Transporter Gene

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