Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization

Vincenzo Zaccone, Alessio Tosoni, Giovanna Passaro, Carla Vincenza Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello, Stefano Carughi, Antonio Greco, Anna Lucia Greco, Anthony Cossari, Francesco Malci, Giulio Ventura

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)


Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving. This is due to Internists’ increased adherence to guidelines and “bundles”. The routine use of SOFA score helps physicians in the definition of septic patients, even if the optimal score has still to come. Point-of-care ultrasonography, lactates, procalcitonin and beta-d-glucan are of help for treatment optimization. The purpose of this narrative review is to focus on the management of sepsis in Internal Medicine departments, particularly on crucial concepts regarding diagnosis, risk assessment and treatment.Key Messages Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The prevalence of sepsis is constantly increasing, affecting more hospital patients than any other disease. At least half of patients affected by sepsis are admitted to Internal Medicine wards. Adherence to guidelines, routine use of clinical and lab scores and point-of-care ultrasonography are of help for early recognition of septic patients and treatment optimization.
Lingua originaleEnglish
pagine (da-a)582-592
Numero di pagine11
RivistaAnnals of Medicine
Stato di pubblicazionePubblicato - 2017


  • Anti-Bacterial Agents
  • Cost of Illness
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Intensive Care Units
  • Internal Medicine
  • Point-of-Care Systems
  • Practice Guidelines as Topic
  • Prevalence
  • Risk Assessment
  • SOFA
  • Sepsis
  • Severity of Illness Index
  • Ultrasonography
  • qSOFA


Entra nei temi di ricerca di 'Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization'. Insieme formano una fingerprint unica.

Cita questo