Sensorimotor cortex excitability and connectivity in Alzheimer's disease: A TMS-EEG Co-registration study

Florinda Ferreri, Fabrizio Vecchio, Luca Vollero, Andrea Guerra, Sara Petrichella, David Ponzo, Sara Määtta, Esa Mervaala, Mervi Könönen, Francesca Ursini, Patrizio Pasqualetti, Giulio Iannello, Paolo Maria Rossini, Vincenzo Di Lazzaro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

47 Citazioni (Scopus)


Several studies have shown that, in spite of the fact that motor symptoms manifest late in the course of Alzheimer's disease (AD), neuropathological progression in the motor cortex parallels that in other brain areas generally considered more specific targets of the neurodegenerative process. It has been suggested that motor cortex excitability is enhanced in AD from the early stages, and that this is related to disease's severity and progression. To investigate the neurophysiological hallmarks of motor cortex functionality in early AD we combined transcranial magnetic stimulation (TMS) with electroencephalography (EEG). We demonstrated that in mild AD the sensorimotor system is hyperexcitable, despite the lack of clinically evident motor manifestations. This phenomenon causes a stronger response to stimulation in a specific time window, possibly due to locally acting reinforcing circuits, while network activity and connectivity is reduced. These changes could be interpreted as a compensatory mechanism allowing for the preservation of sensorimotor programming and execution over a long period of time, regardless of the disease's progression.
Lingua originaleEnglish
pagine (da-a)2083-2096
Numero di pagine14
RivistaHuman Brain Mapping
Stato di pubblicazionePubblicato - 2016


  • Alzheimer's disease
  • Anatomy
  • EEG
  • Navigated transcranial magnetic stimulation
  • Neurology
  • Neurology (clinical)
  • Radiological and Ultrasound Technology
  • Radiology, Nuclear Medicine and Imaging
  • Sensorimotor cortex connectivity
  • Sensorimotor cortex excitability


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