TY - JOUR
T1 - Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life
AU - Panza, Francesco
AU - Lozupone, Madia
AU - Sardone, Rodolfo
AU - Battista, Petronilla
AU - Piccininni, Marco
AU - Dibello, Vittorio
AU - La Montagna, Maddalena
AU - Stallone, Roberta
AU - Venezia, Pietro
AU - Liguori, Angelo
AU - Liguori, Antonio
AU - Giannelli, Gianluigi
AU - Bellomo, Antonello
AU - Bellomo, Alberto
AU - Greco, Antonio
AU - Greco, Andrea
AU - Daniele, Antonio
AU - Seripa, Davide
AU - Quaranta, Nicola
AU - Logroscino, Giancarlo
PY - 2018
Y1 - 2018
N2 - The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer’s disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.
AB - The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer’s disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.
KW - Alzheimer’s disease
KW - age-related hearing loss
KW - auditory system
KW - cognitive functions
KW - dementia
KW - frailty
KW - lifestyle
KW - presbycusis
KW - vascular dementia
KW - Alzheimer’s disease
KW - age-related hearing loss
KW - auditory system
KW - cognitive functions
KW - dementia
KW - frailty
KW - lifestyle
KW - presbycusis
KW - vascular dementia
UR - http://hdl.handle.net/10807/141973
UR - http://www.sagepub.com/journalsproddesc.nav?prodid=journal201940
U2 - 10.1177/2040622318811000
DO - 10.1177/2040622318811000
M3 - Article
SN - 2040-6223
VL - 10
SP - 2040622318811000-N/A
JO - Therapeutic Advances in Chronic Disease
JF - Therapeutic Advances in Chronic Disease
ER -