Semaphorins as Regulators of Phenotypic Plasticity and Functional Reprogramming of Cancer Cells

Luca Tamagnone, Sreeharsha Gurrapu

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

8 Citazioni (Scopus)

Abstract

Semaphorins, initially found as neuronal guidance cues in embryo development, are now appreciated as major regulators of tissue morphogenesis and homeostasis, as well as of cancer progression. In fact, semaphorin signals have a profound impact on cell morphology, which has been commonly associated with the ability to regulate monomeric GTPases, cell-substrate adhesion, and cytoskeletal dynamics. Recently, however, several reports have indicated a novel and additional function of diverse semaphorins in the regulation of gene expression and cell phenotype plasticity. In this review article, we discuss these novel findings, focusing on the role of semaphorin signals in the regulation of bi-directional epithelial-mesenchymal transitions, stem cell properties, and drug resistance, which greatly contribute to the pathogenesis of cancer.
Lingua originaleEnglish
pagine (da-a)303-314
Numero di pagine8
RivistaTrends in Molecular Medicine
Volume25
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Cancer
  • EMT
  • Molecular Biology
  • Molecular Medicine
  • drug resistance
  • neuropilin
  • plexin
  • semaphorin
  • stem cell

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