Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.

Luca Tamagnone, Jyoti Parkash, Andrea Messina, Fanny Langlet, Irene Cimino, Anne Loyens, Danièle Mazur, Sarah Gallet, Eglantine Balland, Samuel A. Malone, François Pralong, Gabriella Cagnoni, Roberta Schellino, Silvia De Marchis, Massimiliano Mazzone, R. Jeroen Pasterkamp, Vincent Prevot, Paolo Giacobini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

61 Citazioni (Scopus)

Abstract

Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine17
RivistaNature Communications
Volume6
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • GnRH
  • PLEXINC1
  • SEMAPHORIN 7A

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